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Volume 8, Issue 5 (Suppl) J Blood Disord Transfus, an open access journal
ISSN:2155-9864 Hematology 2017
November 08-09, 2017
November 08-09, 2017 | Las Vegas, USA
11th International Conference on
Hematology & Hematological Oncology
Hematological profile and ascorbate deficiency among children of African descent with protein energy
malnutrition in Sokoto, NorthWestern Nigeria
Erhabor Osaro1, Jiya N M A2, Abdullahi S1 and Abdulrahaman Y1
1Usmanu Danfodiyo University Sokoto, Nigeria
2Usmanu Danfodiyo University Teaching Hospital, Nigeria
Protein energy malnutrition is the most widespread nutritional deficiency disorder of mankind and continues to be a major
public health burden in developing countries. The aim of this case-control study was to determine the changes in some
hematological parameters, ascorbic acid and pantothenic acid levels among children with Protein Energy Malnutrition (PEM)
in Sokoto, North Western Nigeria. The study included a total of 90 children (47 subjects with PEM and 43 apparently healthy
controls) aged 6 months to 5 years, admitted to the Pediatric Unit of Usmanu Danfodiyo University Teaching Hospital and
Specialist Hospital, Sokoto. Some hematological parameters (packed cell volume, total white blood cell count and platelet
count) were analyzed using the auto-hematology analyzer (Genesis, HA6000). Ascorbic acid levels were assayed by a standard
chemical method. Nutritional status was determined using the Welcome Trust Classification. Data were analyzed using
SPSS 22.0 statistical package. A p-value ≤0.05 was considered significant in all statistical comparisons. The result indicated
that subjects with protein energy malnutrition had a lower mean packed cell volume (25.50±6.83%) compared to controls
(32.73±6.85 %) (p=0.0001). The mean total white cell count was significantly higher among subjects with protein energy
malnutrition (12.16±4.94×109/l) compared to controls (7.59±3.20×109/l) (p=0.0001). There were no statistically significant
differences in themean value of platelet counts of subjects (260.40±148.8×109/l) and controls (1237.61±99.20×109/l) (p=0.400).
The mean value of ascorbic acid was significantly lower among subjects (0.82±0.27 mg/dl) compared to controls (1.06±0.15
mg/dl) (p=0.0001). Children with Kwashiorkor had higher value of packed cell volume compared to those with marasmic-
kwashiorkor (p=0.0001). Children with marasmic-kwashiorkor had a higher total white cell count when compared with
other types of protein energy malnutrition (p= 0.0001). Underweight subjects had lower ascorbic acid levels when compared
with other types of protein energy malnutrition (p=0.0001). Platelet count and pantothenic acid levels showed no significant
difference within the various types of protein energy malnutrition (p=0.331 and 0.391, respectively). This study has shown
that children with protein energy malnutrition have lower packed cell volume and ascorbic acid levels compared to controls.
The total white cell count was higher among children with protein energy malnutrition compared to controls. Protein energy
malnutrition was more prevalent among children from low socioeconomic class whose mothers have no formal education.
Marasmus was the most common type of protein energy malnutrition. Children with kwashiorkor have a higher packed cell
volume compared to other types of protein energy malnutrition. Total white blood cell count of children with marasmic-
kwashiorkor was significantly higher compared with other types. Immune boosters (vitamins and other micronutrient)
should be provided for school children particularly children with protein energy malnutrition. There is need for infant feeding
practice to be strengthened by promoting exclusive breast feeding. There is need for increased enrollment of women in schools,
enlightenment on nutritional education and empowerment so as to improve their socioeconomic status.
Biography
Erhabor Osaro is a Professor of Hematology, Blood Transfusion Medicine and Laboratory Total Quality Management. He has received his PhD in Immuno-Hema-
tology from the Rivers State University of Science and Technology in Port Harcourt, Nigeria. He is also an Alumni of University of Greenwich in the United Kingdom
and Francis Tuttle College of Technology in Oklahoma, USA. Currently, he is a Professor in Usmanu Danfodiyo University, Sokoto, Nigeria, where he teaches best
practices in hematology, blood transfusion science and laboratory total quality management. He has more than 200 published articles in both local and international
journals, 5 scientific books and 5 chapters of scientific books. He is on the Editorial Board of several reputable local and international journals and Editor-in-Chief
of the renowned Sokoto Journal of Medical Laboratory Science. He is an expert reviewer to several international scientific journals. He has recently bagged the
Specialist Certificate in Blood Transfusion Science Practice (SCTSP) from the British Blood Transfusion Society in the United Kingdom. He is a recipient of several
awards and honors including the Margaret Kenwright Award from the British Blood Transfusion Society (BBTS). He is the President of Board of Directors of Nelon
Medical Limited, UK.
Erhabor Osaro et al., J Blood Disord Transfus 2017, 8:5 (Suppl)
DOI: 10.4172/2155-9864-C1-028