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conferenceseries
.com
Volume 8, Issue 10 (Suppl)
J Diabetes Metab
ISSN: 2155-6156 JDM, an open access journal
Herbal Diabetes 2017
November 02-04, 2017
November 02-04, 2017 Bangkok, Thailand
23
rd
International Conference on
Herbal and Alternative Remedies for
Diabetes and Endocrine Disorders
The anti-diabetic effect of
Lupine turmos
compared with anti-diabetic drug Glibenclamide
Laila E Taha
Alzaiem Alazhari University, Sudan
Statement of the Problem:
The problem of the study lied behind the fact that Sudanese diabetic patients are using some plants
as a treatment, without any experimental data on their biological effects, their suitable dose and their role in diabetic treatment.
Some diabetic patients are suffering from side effects of anti-diabetic drugs.
Purpose:
To determine the biological effects of
Lupine turmos
which is used traditionally by diabetic Sudanese patients
comparing with anti-diabetic drug Glibenclamide.
Methodology:
The essays of the present study were conducted on albino rats which obtained from the faculty of pharmacy,
University of Khartoum, Sudan. 30 albino rats of either sex weighing (135-250 g) and aged two months were used. 6 animals
served as control, 6 animals were treated with anti-diabetic drug (Glibenclamide10 gm/kg-body-weight) and 18 animals (three
groups N=6) were administered with three different doses (200, 400 and 800 mg/kg-b.w) respectively. Blood specimens were
collected from each group and serum levels of blood glucose, lipid profile and α-amylase concentrations were estimated.
Findings:
The results shows an insignificant difference between the means of blood glucose in the two treated groups, group
(4) which was treated with (400 mg/kg-b.w)
Lupine turmos
aqueous extract (blood glucose-111.9 mg/dl) and group (2) with
(10 mg/kg-b.w) Glibenclamide (blood glucose-98.416 mg/dl). Cholesterol and triglycerides of treated groups were the same as
group (3) with (10 mg/kg-b.w) Glibenclamide, there was no significant difference between two groups and control group. The
aqueous extract of the plant inhibited α-amylase enzyme activity at a dose (200 mg/kg-b.w), in group (3) versus group (2) with
Glibenclamide drug there was no significant difference between two groups (p≤0.05).
Conclusion & Significance:
It can be concluded from this study that
Lupine turmos
aqueous extract have a hypoglycemic effect
by reducing both blood glucose and α-amylase enzyme without any side effects.
laila3md@gmail.comJ Diabetes Metab 2017, 8:10 (Suppl)
DOI: 10.4172/2155-6156-C1-073