3 / 22
Page 41
Notes:
conferenceseries
.com
Volume 8, Issue 10 (Suppl)
J Diabetes Metab
ISSN: 2155-6156 JDM, an open access journal
Herbal Diabetes 2017
November 02-04, 2017
November 02-04, 2017 Bangkok, Thailand
23
rd
International Conference on
Herbal and Alternative Remedies for
Diabetes and Endocrine Disorders
Uncaria tomentosa
prevents non-alcoholic steatohepatitis and improves insulin sensitivity in diet
induced and genetic obese mice
Layanne C C Arauj, Isadora C Furig, Gilson M Murata, J Donato Jr, Silvana Bordin, Rui Curi and Carla R O Carvalho
University of São Paulo, Brazil
T
he Non-Alcoholic Fatty Liver Disease (NAFLD) is a clinical manifestation of metabolic syndrome. With the worldwide
increase in obesity, there is also a burden of NAFLD that is estimated in the range of 20-30%. NAFLD includes the benign
hepatic steatosis and the hepatic steatosis associated with inflammatory infiltrates, the Non-Alcoholic Steatohepatitis (NASH).
NASH may lead to liver cirrhosis and to Hepatocellular Carcinoma (HCC) and about 10 to 20% of people with NAFLD
develop NASH. Therefore, we investigated the effect of the herbal extract Uncaria tomentosa (Ut) (50 mg/kg, crude extract,
for 5 consecutive days) on the Non-Alcoholic Fatty Liver Disease (NAFLD) of the Diet-Induced Obese (DIO) and genetically
obese (ob/ob) mice. Both obese mice exhibited lipid droplets in the liver. The DIO mice had macro vesicular steatosis, whereas
the ob/ob mice exhibited micro vesicular steatosis. The Ut treatment induced 35% and 20% reduction in the number of lipid
droplets in the both obese animals, respectively. The Ut treatment reduced the serine phosphorylation of IRS-1 by 25% and by
40%, in the liver of DIO and of ob/ob mice respectively. Furthermore, the Ut treatment improved the inflammatory balance
in the liver of both obese animals. There were reduced pro-inflammatory index (mRNA IL-1b/IL-10) to approximately 20%
and decreased the pro-macrophage activation (mRNA F4/80/Arginase-1) to 12% in the DIO mice and reduced to 39% the
pro-macrophage activation in the ob/ob mice compared to respective vehicle controls. Results herein reported, prompted to
the conclusion that
Uncaria tomentosa
not only improves insulin sensitivity but also transforms NASH to a benign hepatic
steatosis in two distinct models of obese mice. These effects are associated with a reduction in inflammatory conditions and
decreased liver steatosis (steatohepatitis).
Biography
Layanne C C Arauj has her graduation degree in Biomedicine, Masters in Cell and Molecular Biology and she is currently a Doctoral student in Human Physiology
at the Biomedical Sciences Institute of the University of São Paulo, working on various subjects like obesity, insulin resistance, hepatic steatosis and intestinal
microbiota in the Laboratory of Intracellular Signaling.
lay_biomed@yahoo.com.brLayanne C C Arauj et al., J Diabetes Metab 2017, 8:10 (Suppl)
DOI: 10.4172/2155-6156-C1-073