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conferenceseries
.com
Volume 7, Issue 4 (Suppl)
Med Chem (Los Angeles), an open access journal
ISSN: 2161-0444
Medicinal Chemistry 2017
June 07-08, 2017
Medicinal Chemistry and Drug Design
6
th
World Congress on
June 07-08, 2017 Milan, Italy
N Nadaraia et al., Med Chem (Los Angeles) 2017, 7:4 (Suppl)
DOI:10.4172/2161-0444-C1-031
5
α
-steroidal amines: Synthesis and biological activity
N Nadaraia, M Merlani, N Barbakadze, N Amiranashvili
and
M Kakhabrishvili
Tbilisi State Medical University, Georgia
S
teroidal amines are characterized with wide spectrum of pharmacological activities such as antitumor, anti-inflammatory,
antibacterial and anti-arrhythmic activity. On the basis of epiandrosterone acetate, product of transformation of tigogenin
(isolated from plant
Yucca gloriosa
), eight possible epimer of 3-amino-17-hydoxy- and 17-amino-3-hydroxy-5
α
-androstane have
been synthesized and their radioprotective and antiarrhythmic activities have been investigated. Among epimeric aminoalcohols
the highest radioprotective activity showed 3
β
-amino-5
α
-androstan-3
β
-ole, while with the highest antiarrhythmic activity is
characterized 17β-amino-5
α
-androstan-3β-ole. Based on these results some conclusion about structure- activity relationship of
synthesized compounds could be made. For radioprotective activity more profitable is diaxial orientation of amino- and hydroxy
groups; whereas, diequatorial orientation is favorable for the antiarrhythmic activity. Some synthesized of N-alkyl- andN-dialkylamino
acetyl derivatives of 17β-amino-5
α
-androststan-3β-ole and 17β-amino-5
α
-androst-2-ene exhibit antiviral, antitubercular and
antitumor activities.
Biography
N Nadaraia has completed her PhD from Mendeleev Moscow Chemical-Technological Institute. She is a lead research scientist at Tbilisi State Medical University.
Her field of interest is a Chemistry and synthesis of biologically active compounds. She is the author of more than 40 papers in reputed journals and has presented
at 50 international scientific conferences.
nnadaraia@ymail.com