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Volume 8 Journal of Obesity & Weight Loss Therapy Nutrition Conference 2018
October 08-09, 2018
October 08-09, 2018 Dubai, UAE
World Congress on
Nutrition and Obesity prevention
The effect of viscous indigestible polysaccharide on body composition and plasma hormones in rats
Ajmila Islam
American University in Dubai, UAE
Dietary interventions that reduce accumulation of body fat are of great interest. Consumption of viscous dietary fibers causes
well-known positive metabolic effects, such as reductions in the postprandial glucose and insulin concentrations. However,
their effect on body composition and fuel utilization has not been previously studied. To examine this, rats were fed a viscous non-
fermentable dietary fiber, Hydroxypropyl Methylcellulose (HPMC), for 6 weeks. Body composition was measured by Dual-energy
X-ray Absorptiometry (DXA) and fat pad weight. Plasma adipokines, AMP kinase activation and enzyme and mRNA analysis of key
regulators of energetics in liver and soleus muscle were measured. The HPMC diet significantly lowered percent body fat mass and
increased percent lean body mass, compared to a cellulose-containing diet (no viscosity). Fasting leptin was reduced 42% and resistin
28% in the HPMC group compared to the cellulose group. Rats fed HPMC had greater activation of AMP kinase in liver and muscle
and lower Phosphoenolpyruvate Carboxykinase (PEPCK) expression in liver. mRNA expression in skeletal muscle was significantly
increased for Carnitine Palmitoyltransferase 1B (CPT-1B), PPARγ co-activator 1α, PPARδ and Uncoupling Protein 3 (UCP3) was
Citrate Synthase (CS) activity, in the HPMC group relative to the cellulose group. These results indicated that viscous dietary fiber
preserves lean body mass and reduces adiposity, possibly by increasing mitochondrial biogenesis and fatty acid oxidation in skeletal
muscle and thus represents a metabolic effect of viscous fiber not previously described. Thus, viscous dietary fiber may be a useful
dietary component to assist in reduction of body fat.
Biography
Ajmila Islam is an Assistant Professor of Natural Sciences at the American University in Dubai. Her PhD research was focused on the relation of diet in terms of reducing the
risk of cancer. She has also worked in the area of Microbiology and Molecular Biology. She has published research in the area of colorectal cancer and obesity.
Ajmila Islam, J Obes Weight Loss Ther 2018, Volume 8
DOI: 10.4172/2165-7904-C8-078