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Volume 7, Issue 7 (Suppl)
J Obes Weight Loss Ther, an open access journal
ISSN:2165-7904
Obesity & Fitness Expo 2017
November 13-15, 2017
November 13-15, 2017 | Atlanta, USA
17
th
World Fitness Expo
16
th
International Conference and Exhibition on
Obesity & Weight Management
&
Nanosized soy phytosome-based thermogel formulation for treatment of obesity, characterization and
in
vivo
evaluation
Nermeen Magdy
1
, Shahira F El-Menshawe
2
, Adel A Ali
2
and
Mohamed A Rabeh
3
1
Nahda University, Egypt
2
Beni-Suef University, Egypt
3
Cairo University, Egypt
O
besity has become an increasing problem over recent years. Nano lipo-vesicles hydrogels of soy saponin were formulated and
evaluated in an attempt to reduce the size of adipose tissue cells through percutaneous absorption. Phytosome formulations were
prepared with four different techniques: Solvent evaporation, anti-solvent precipitation, co-solvency and mechanical dispersion. Best
formulae was selected by the means of the highest entrapment efficiency, minimum particle size and maximum drug release and then
evaluated for successful complex formation by means of FTIR. Particles zeta potential was detected and particles shape was evaluated
using TEM to insure particles spherical shape. Selected phytosome formulae was involved into selected hydrogel formulae after
evaluation of different plain hydrogel formulations for its clarity, homogenity, pH, gel transforming temperature and viscosity study.
The obtained phytosomal hydrogel formulae were then re-evaluated for its clarity, homogeneity, pH and gel transforming temperature
and for its rheology behavior and permeation study.
In vivo
study was done to ensure anti-obesity effect of soy phytosomal hydrogel.
Concisely, soy phytosomal hydrogel was found to have the ability to reduce the size of adipose tissue cells in male albino rats.
nermeen.magdy@nub.edu.egJ Obes Weight Loss Ther 2017, 7:7 (Suppl)
DOI: 10.4172/2165-7904-C1-55