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Volume 10
Journal of Cancer Science & Therapy
Oncologists 2018
May 24-25, 2018
Page 15
Notes:
conference
series
.com
May 24-25, 2018 Osaka, Japan
22
nd
Global Annual Oncologists Meeting
Multiple roles of the cytoskeletal protein, gelsolin, in gastrointestinal tumor cells that contribute to
dissemination and tumor progression
G
elsolin is an actin-binding protein which regulates the dynamics of the actin cytoskeleton and is involved in several
pathological conditions including cancer. The roles of gelsolin in cancer are complex, there is evidence that it contributes
to both tumor suppression as well as malignant progression. Studies suggest that gelsolin can act as a tumor suppressor, with
decreased expression of gelsolin observed in cancers such as breast and lung cancers. On the other hand, high gelsolin expression
has been correlated with aggressive tumors, such as with high grade urothelial and oral carcinomas, and lymphatic invasion in
lung cancer. We identified gelsolin expression to be up-regulated in tumor tissues which exhibit disseminative behavior, such
in lymph node metastases of intestinal-type gastric cancer, in primary tumors of diffuse gastric cancer and at the invasive edges
of colon cancer metastases in the liver. We found that gelsolin can promote dissemination of gastrointestinal cancer cells by
several mechanisms-gelsolin dysregulates the cellular redox milieu and promotes extracellular matrix degradation, leading to
increased invasive activity of cancer cells. Gelsolin also interacts with the Hepatocyte Growth Factor (HGF)-cMET pathway
and affects intercellular adhesion to promote cell scattering. In addition, gelsolin protects cancer cells from stress by activating
autophagy. The multiple roles of gelsolin that contribute to cancer progression will be discussed.
Biography
Celestial T. Yap has obtained MBBS degree from the National University of Singapore. She is engaged in clinical practice and subsequently obtained a PhD in
Biomedical Sciences at the University of Edinburgh, UK. She is the Physiology Program Director and the Integration Lead Educator at the Yong Loo Lin School of
Medicine, NUS, overseeing undergraduate education in clinical sciences. She leads the cytoskeleton and tumor biology laboratory, which focuses on cytoskeletal
derangements and signaling pathways that promote tumor invasion and resistance, as well as biomarkers for cancer detection.
phsyapc@nus.edu.sgCelestial T. Yap
National University of Singapore, Singapore
Celestial T. Yap, J Cancer Sci Ther 2018, Volume 10
DOI: 10.4172/1948-5956-C3-128