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Volume 10 Journal of Cancer Science & Therapy Oncologists 2018
May 24-25, 2018
May 24-25, 2018 Osaka, Japan
22nd Global Annual Oncologists Meeting
Novel roles of gelsolin, a cytoskeletal protein, in regulating chemoresistance and cancer cell survival
Shuo Deng1, Tuan Zea Tan1, Tamilarasi Jegadeesan 1, Liming Wang1, Henry Yang1, Alan Prem Kumar1, 2, 3, Han-Ming Shen1, 3 and Celestial T Yap1, 3
1National University of Singapore, Singapore
2Curtin University, Australia
3National University Health System, Singapore
C olorectal cancer is one of most common types of cancer worldwide. Current first line chemotherapeutic treatment of
colorectal cancer comprises 5-fluorouracil (5-FU)-based regimen. However, response to 5-FU-based therapy varies in
patients and development of drug resistance also impedes the effectiveness of treatment. Therefore, there is a pressing need
to understand the mechanisms of drug resistance and identify new targets to help overcome chemoresistance. Accumulating
evidence suggest that regulators of actin cytoskeleton play critical roles in the resistance to treatment and disease progression,
via modulating cell survival/cell death pathways. Herein, we identify that gelsolin, an actin depolymerizing factor, contributes
to resistance to 5-FU in colorectal cancer cells. Using colorectal cancer cell lines, we showed that gelsolin protected cells
from 5-FU-induced cell death, while reducing gelsolin levels could sensitize cells to 5-FU treatment. Furthermore, gelsolin
modulated autophagy, an important cell survival process against stresses, as a cytoprotective mechanism in response to
5-FU. We also demonstrate that gelsolin could be a potential prognostic marker for colorectal cancer patients, where patients
with high levels of gelsolin and autophagy-regulating proteins showed shorter disease-free survival, compared to those with
lower expression levels. In summary, we demonstrated a role of gelsolin in regulating autophagy, which contributes to 5-FU
resistance in colorectal cancer cells. Our findings highlight gelsolin as a potential target for combating resistance to 5-FU based
chemotherapy, and as a possible prognostic factor in patient survival.
Biography
Shuo Deng has completed her PhD from National University of Singapore and continued her Postdoctoral training at Yong Loo Lin School of Medicine, National
University of Singapore. She has published more than six papers in reputed journals and has been serving as a Reviewer in reputed journals.
Shuo Deng ., J Cancer Sci Ther 2018, Volume 10
DOI: 10.4172/1948-5956-C3-129