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.com

Volume 10

Journal of Cancer Science & Therapy

Oncologists 2018

May 24-25, 2018

May 24-25, 2018 Osaka, Japan

22

nd

Global Annual Oncologists Meeting

Novel roles of gelsolin, a cytoskeletal protein, in regulating chemoresistance and cancer cell survival

Shuo Deng

1

, Tuan Zea Tan

1

, Tamilarasi Jegadeesan

1

, Liming Wang

1

, Henry Yang

1

, Alan Prem Kumar

1, 2, 3,

Han-Ming Shen

1, 3

and Celestial T Yap

1, 3

1

National University of Singapore, Singapore

2

Curtin University, Australia

3

National University Health System, Singapore

C

olorectal cancer is one of most common types of cancer worldwide. Current first line chemotherapeutic treatment of

colorectal cancer comprises 5-fluorouracil (5-FU)-based regimen. However, response to 5-FU-based therapy varies in

patients and development of drug resistance also impedes the effectiveness of treatment. Therefore, there is a pressing need

to understand the mechanisms of drug resistance and identify new targets to help overcome chemoresistance. Accumulating

evidence suggest that regulators of actin cytoskeleton play critical roles in the resistance to treatment and disease progression,

via modulating cell survival/cell death pathways. Herein, we identify that gelsolin, an actin depolymerizing factor, contributes

to resistance to 5-FU in colorectal cancer cells. Using colorectal cancer cell lines, we showed that gelsolin protected cells

from 5-FU-induced cell death, while reducing gelsolin levels could sensitize cells to 5-FU treatment. Furthermore, gelsolin

modulated autophagy, an important cell survival process against stresses, as a cytoprotective mechanism in response to

5-FU. We also demonstrate that gelsolin could be a potential prognostic marker for colorectal cancer patients, where patients

with high levels of gelsolin and autophagy-regulating proteins showed shorter disease-free survival, compared to those with

lower expression levels. In summary, we demonstrated a role of gelsolin in regulating autophagy, which contributes to 5-FU

resistance in colorectal cancer cells. Our findings highlight gelsolin as a potential target for combating resistance to 5-FU based

chemotherapy, and as a possible prognostic factor in patient survival.

Biography

Shuo Deng has completed her PhD from National University of Singapore and continued her Postdoctoral training at Yong Loo Lin School of Medicine, National

University of Singapore. She has published more than six papers in reputed journals and has been serving as a Reviewer in reputed journals.

[email protected]

Shuo Deng

et.al

., J Cancer Sci Ther 2018, Volume 10

DOI: 10.4172/1948-5956-C3-129