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Volume 8 Journal of Clinical & Experimental Pathology Pathology Summit 2018
July 02-03, 2018
Page 13
conferenceseries.com
July 02-03, 2018 Bangkok, Thailand
15th Global Experts Meeting on
Pathology and Laboratory Medicine
Regulatory peptides: The mechanisms of effects on the pain-induced aggressive-defensive behavior
For many years we have studied the regulatory peptides effects on the integration of nervous, endocrine and immune
mechanisms in the pain-induced aggressive-defensive behavior in rat. 23 analogues of the natural hypothalamic-pituitary
peptides and other peptides synthesized in the Russian Academy of Sciences and “Serva” were administered in intra-peritoneal
and brain intra-ventricular injections. With the use of the modified foot-shock model the following regularities of peptide
effects were revealed. (1) The key role in peptide effects is played by the L-arginine or L-lysine amino acids residues. In
particular, only the administration of arginine containing peptides increased pain sensitivity and aggression, (2) binding of the
tripeptide Pro-Gly -Pro to the amino acid (Arg) or oligopeptide (ACTH 4-7) essentially modifies the influence on the affective
aggression, (3) the intensity of aggression depends on the excitability of the brain emotional negative systemmore than on pain
perception. This was demonstrated due to effects of encephalin analogues, (4) peptide effects seemed to be dependent on the
brain locus of their primary application and (5) neuropeptide effects were more expressed in rats with the higher excitability
of nociceptive, emotional, opioid and M-cholinergic systems. Since analogues of the natural peptides have been used, there is
a reason to believe that obtained data make it possible to elucidate the mechanisms of the development of the pain-induced
affective aggression and to develop means for its correction.
Biography
Severyanova L A has performed research at Kursk State Medical University and received her PhD and later Russian “Doctor of Medicine” at the Pavlov Institute
of Physiology of the Russian Academy of Sciences. She has been the Head of the Department of Pathophysiology, Dean of the International Faculty, Professor of
Pathophysiology and Honored Worker of Higher School. Her scientific interest is the integration of nervous, endocrine and immune mechanisms in the systemic
reactions of the body. She has published more than 50 articles in reputed journals and three monographs.
Severyanova L A
Kursk State Medical University, Russia
Severyanova L A, J Clin Exp Pathol 2018, Volume 8
DOI: 10.4172/2161-0681-C2-047