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Volume 7, Issue 4 (Suppl) Pediatr Ther, an open access journal
ISSN: 2161-0665 Pediatric Cardiology & ICND 2017
October 16-18, 2017
October 16-18, 2017 New York, USA
3rd Annual Summit on
&
Clinical Pediatrics and Cardiology
Infancy, Child Nutrition and Development
The negative effects of pre-pregnancy and pregnancy diabetes on neurodevelopment and metabolism of
newborn: Screening and foetal programming for the prevention
Diabetes and related complications are very problematic in a pregnancy for maternal and fetal health. This research is a focus
on women in pre-pregnancy and pregnancy, in particulary the attention is about risk factors as obesity, genetic conditions,
familiar preeclampsia and metabolic diseases. This research is divided into parts: first is the analysis of diabetes conditions
and consequences, in a pregnancy, for neurodevelopment of newborn and the second is an educational foetal programming
for prevention. The problems are related in seven cases on 10 to diabetes mellitus in pre-pregnancy. In a cohort study on 92
women, 45 in pregnancy and 47 in pre-conceptional age, only 10% of pregnant women and 3% of non- pregnant know their
diabetic conditions. In pre-pregnancy the diabetes andmalnutrion, in association with a bad lifestyle, create a pre-inflammatory
conditions with oxidation reactions, dangerous for mitochondrial genomic and for regulation of gene expression in future
fetal development. Infact in this study in women with pre-pregnancy diabetes as new condition, the related complications
as hypertension and metabolic scompenses was evident in 15 women, with overweight or obesity too. After this study the
screening revealed in 15 cases the diabetes condition and complications with hypertension and hyperglycemia, in particulary
the consequence was the influences for fetal nutrition and neurodevelopment. The epigenetic effect of inflammatory status
caused a vasoconstriction and damage against tissues in development in particulary neuromuscular structures. The foetal
programming and educational diabetics screening is the purpose for improvement in the pre-pregnancy health for a future life.
Biography
Barbara Hugonin did her Bachelor of Biological Sciences in University of Naples, Master’s degree in Human Genetics and Genomics on prenatal diagnosis, cytoge-
netics, screening for inherited inborn error of metabolism and screening programming in Children’s hospital of Florence and one more Master’s degree in molecular
and medical genetics and genetic pathologies. Her research and training programme includes Counseling genetics (2015-now) and research in maternal fetal
nutrition and metabolic conditions. She is working for a Preconceptional Health Education Programme, The National Institute of Health in Rome, the group GLISP
(Group of work for preconceptional health). She is a Diabetes Pediatric, Maternal Educator as well as Genetic Counselor.
Barbara Hugonin
University of Siena, Italy
Barbara Hugonin, Pediatr Ther 2017, 7:4 (Suppl)
DOI: 10.4172/2161-0665-C1-044