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conferenceseries.com
Volume 7, Issue 5 (Suppl) J Psychol Psychother, an open access journal
ISSN: 2161-0487 Psychosomatic Medicine & Forensic Congress 2017
October 12-14, 2017
JOINT EVENT
24th International Conference on PSYCHIATRY & PSYCHOSOMATIC MEDICINE
2nd International Congress on FORENSIC SCIENCE AND PSYCHOLOGY
&
October 12-14, 2017 London, UK
Are mast cells the key to multiple sclerosis (MS)?
Per Goran Kruger
University of Bergen, Norway
MS may not be an autoimmune genetic disease. Since the ninety-fifties the opposite statement has strangulated most scientific
approaches to the understanding of MS. Mast cells are aggregated along venules in border zones of the MS-plaques, and if
stimulated releases specific mediators as histamine, resulting in oedema formations normally observed in the early onset of MS, as
well as proteases that may cause demyelinization. The numbers of mast cells in the plaque-border zones of females is approximately
doubled from that in males, which may explain the fact that females are more inclined to developing MS than males. Mast cells may
be stimulated by various stress phenomenon, which in itself forward the possibility that MS is a sociocultural phenomenon. This is
also strengthened by the observation that fragments of secreted chromogranins from the entro-endocrine system stimulate mast
cells to secretion. The fact that stimulated mast cells survive, and within weeks/months may fully reload, may explain the frequent
relapsing-remitting alternating phases of MS.
Biography
Per Goran Kruger, professor emeritus . Studied biology in Bergen, Norway on mast cells in the brain of wake and hibernating hedgehogs. Studied the mechanism
of histamine secretion from mast cells at Karolinska institute Stockholm, Sweden and at Inst. of pathology in Seattle, USA. In the seventhies he opposed to the
planned fluoridation of Norwegian drinking waters (Which never started after that). Last 30 years engaged in multiple sclerosis and points to the obvious connection
to mast cells. Received students price for not using power point when teaching cell biology and histology.
Per Gøran Krüger, J Psychol Psychother 2017, 7:5(Suppl)
DOI: 10.4172/2161-0487-C1-017