std-asia-pacific-2017-posters-accepted-abstracts

Page 54

conferenceseries

.com

Volume 8, Issue 9 (Suppl)

J AIDS Clin Res

ISSN: 2155-6113 JAR, an open access journal

STD Asia Pacific 2017

October 23-25, 2017

OCTOBER 23-25, 2017 OSAKA, JAPAN

ASIA PACIFIC

STD and Infectious Diseases Congress

Direct evidence of viral infection and mitochondrial alterations in the brain of fetuses at high risk for

schizophrenia

Segundo Mesa Castillo

Havana Psychiatric Hospital, Cuba

here is increasing evidences that favor the prenatal beginning of schizophrenia. These evidences point toward intra-uterine

environmental factors that act specifically during the second pregnancy trimester producing a direct damage of the brain

of the fetus. The current available technology does not allow observing what is happening at cellular level since the human

brain is not exposed to a direct analysis in that stage of the life in subjects at high risk of developing schizophrenia. In 1977,

we began a direct electron microscopic research of the brain of fetuses at high risk from schizophrenic mothers in order to

find differences at cellular level in relation to controls. In these studies, we have observed within the nuclei of neurons, the

presence of complete and incomplete viral particles that reacted in positive form with antibodies to herpes simplex hominis

type I [HSV-1] virus and mitochondria alterations. The importance of these findings can have practical applications in the

prevention of the illness keeping in mind its direct relation to the etiology and physiopathology of schizophrenia. A study of

amniotic fluid cells in women at risk of having a schizophrenic offspring is considered. Of being observed, the same alterations

that those observed previously in the cells of the brain of the studied fetuses it would intend to these women in risk of having a

schizophrenia descendant, previous information of the results, the voluntary medical interruption of the pregnancy or an early

anti HSV-1 viral treatment as preventive measure of the later development of the illness.