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Volume 3, Issue 1 (Suppl) Toxicol Open Access
ISSN: 2476-2067 TYOA, an open access journal Toxicology Congress 2017
April 13-15, 2017
April 13-15, 2017 Dubai, UAE
8th World Congress on
Toxicology and Pharmacology
Baclofen systemic toxicity: Experimental histopathological and biochemical study
Sahar Y Issa1, Essam M Hafez2, Asmaa S El-Banna1, Safaa M Abdel Rahman3, Maha K AlMazroua4 and Mostafa Abo El-Hamd2
1Alexandria University Faculty of Medicine, Egypt
2Minia University, Egypt
3Central Laboratory, Egypt
4Dammam Poison Control Center, KSA
The study was performed on 30 healthy adult male Albino rats divided into four groups with five rats in each control
group, and ten rats in either experimental groups (two experimental and two control groups). Five rats (negative control)
were kept in a quite non-stressful environment, provided with food ad libitum and free access to water. Normal saline (1
ml) was given orally as placebo in the positive control group (n=5). Experimental group III, Baclofen acute toxicity group
(10 rats): Each animal received a single dose of LD50 of Baclofen orally
by gavage. It equals 145 mg/kg b wt. The rats were observed for acute
toxicity manifestations as well as for LD50 deaths. Group IV, (Baclofen
dependent group 10 rats): Each animal received Baclofen (1/10th LD50)
in gradually increasing doses for one month. The levels of blood urea
nitrogen (BUN), creatinine kinase (CK), alanine aminotransferase
(ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP),
gamma-glutamyl transpeptidase (GGT), cardiac troponin I (CTnl),
prothrombin time (PT), in both Baclofen treated groups showed
significant elevation when compared to controls. There were brain, lung,
gastric, hepatic, and renal histopathological changes in Baclofen treated
rats whose severity varied between the two experimental groups.
Biography
Sahar Y Issa has completed her Doctorate degree in Clinical Toxicology & Forensic Medicine in 2008, from Faculty of Medicine, Alexandria University, Egypt and
is a Lecturer of Clinical Toxicology & Forensic Medicine in the same University. She is currently a Consultant Toxicologist, and the Medical Director, supervising
Emergency Toxicology, Molecular Toxicology, & Therapeutic Drug Monitoring units in Dammam Poison Control Center, MOH - Saudi Arabia. She has published
more than 25 papers in reputed journals and serving as an Editorial Board Member of repute.
Sahar Y Issa et al., Toxicol Open Access 2017, 3:1 (Suppl)
Figure 1: Renal tissue in different groups