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Volume10, Issue 12 (Suppl) J Proteomics Bioinform, an open access journal
ISSN: 0974-276X
Page 56
conferenceseries.com
World Biomarkers & Pharma Biotech 2017
December 07-09, 2017
December 07-09, 2017 | Madrid, Spain
&
20th International Conference on
PHARMACEUTICAL BIOTECHNOLOGY
9th WORLD BIOMARKERS CONGRESS
JOINT EVENT ON
Association of humanpapilloma viruswithhead andneck cancerpatients fromKhyberPakhtunkhwa,
Pakistan
Maimoona Sabir
University of Haripur, Pakistan
Head and neck cancer (HNC) is the sixth most common cancer causing a high mortality rate worldwide. There are number of
risk factors involved in head and neck cancer such as tobacco, alcohol, radiations, inhaling asbestos, wood dust, paint fumes
and viruses. Most common virus involved in the subset of head and neck cancer is human Papilloma virus (HPV). Human papilloma
virus is double stranded DNA virus which is about 8Kb surrounded by protein coat consisting of two proteins L1 and L2. Out of 100
different types of HPV 15 are considered as highly pathogenic. HPV is divided into two major types; High risk HPV and Low risk
HPV. In current study 150 HNC patients were screened for HPV genotyping and risk factors possibly associated with HNC. DNA was
extrracted by standard phenol chloroform extraction method followed by HPV genotyping by polymerase chain reaction and agarose
gel electrophoresis. In study, among the HNC affected individuals 81(54%) were HPV+ive and 69 (46%) HPV–ive. Statistically, no
significant difference was observed between HPV+ive and HPV-ive. HNC cases in terms of gender. In terms of age group, statistically
no significant difference was observed between two groups (age group >40, <40). With respect to anatomic site of head and neck
cancer patients, highest number of HPV+iv was observed in oral cavity 51(63%) followed by pharynx 20(25%), larynx 7(8%) and
hypopharynx 3(4%). Disease was more common among illiterate individuals with low socioeconomic status and trend of HPV+ive
HNC cases have increaed from year 2011 to 2016. It can be concluded from the data that HPV infection can be the main risk factor
for HNC cases in Pakistan. Further research is needed to elucidate the mechanism involved in HPV infection with head and neck
carcinogenesis.
Biography
Maimoona Sabir has completed her PhD from the Department of Biosciences, COMSATS, Institute of Information Technolgy, Islamabad, Pakistan. She is currently
working as Assistant Professor in the Department of Microbiology, University of Haripur, KP, Pakistan. She has published more than 15 reserach papers in reputed
journals. She has won grant from Higher Education Commssion of Pakistan for research work, “role of HPV in head and neck cancer in Pakistani population”.
Maimoona Sabir, J Proteomics Bioinform 2017, 10:12(Suppl)
DOI: 10.4172/0974-276X-C1-109