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Volume 4, Issue 2 (Suppl) J Pigment Disord
ISSN: 2376-0427 JPD, an open access journal World Dermatology Congress 2017
September 25-26, 2017
September 25-26, 2017 Dubai, UAE
17th World Dermatology Congress
Efficacy and safety of combination therapy in androgenetic alopecia: Randomized uncontrolled
evaluator blind study
Shivani Dhande, Sanjiv Choudhary and A L Singh
Datta Meghe Institute of Medical Sciences, India
Introduction & Aim: Early age of onset for baldness has marked psychological impact on personality. Combination therapies
have better efficacy than monotherapy in androgenetic alopecia. Although medical, surgical treatment and cosmetic aids are
available for treatment of pattern baldness, medical is first preferred line of treatment. Although only 5% topical Minoxidil
is USFDA approved, 10% is available in India since 2007. Efficacy of tablet Finasteride is well established in male pattern
baldness. 5% topical Minoxidil is effective and safe in female pattern baldness. There is a role of saw palmetto in regrowth of
scalp hair. With this background research was undertaken to study efficacy and safety of topical Minoxidil 10%+Finesteride
tablet (1 mg)+dermaroller in male pattern baldness and topical Minoxidil 5%+Saw palmetto capsule (320 mg)+dermaroller in
female pattern baldness.
Methods & Materials: It is a randomized uncontrolled evaluator blind study consisting of total 21 patients, 15 of male pattern
baldness and 6 of female pattern baldness within 20-35 years of age were enrolled. Male patients had Hamilton grade 2-4 MPB
and females had Ludwig grade 2 FPB. Male patients were treated with tablet Finesteride 1 mg once daily+10% topical Minoxidil
1 ml twice daily for 6 months. Female patients were treated with capsule Saw palmetto 320 mg once daily+5% topical Minoxidil
twice daily for 6 months. In both male and female patients dermaroller therapy was used once in 10 days for 4 sittings followed
by once in 15 days for next 5 months. Blood pressure and possible side effects were monitored in every follow up visits. Pre and
post treatment photographs were taken. Assessment of hair growth was done at baseline and at the end of 6 months. Patients’
satisfactory grading scale and physician assessment of hair growth scale were used to assess the results. TrichoScan was done
for assessment of hair-shaft diameter and density. Pre and post treatment photographs and TrichoScan hair growth analysis (by
diameter and density) was done by physician (dermatologist) not directly involved in this study (evaluator blind).
Result: This combination therapy showed moderate response in female pattern alopecia and good to excellent results in male
pattern alopecia at the end of 6 months. During therapy none of the patients showed side effects like hypotension, headache
and loss of libido, hirsuitism. Mild irritation due to crystal deposition was noted by 3 patients.
Conclusion: Effective and early treatment using combination therapy with higher percent of Minoxidil for rapid hair growth
is necessary in initial period since it will boost up the self-confidence in patients leading to better treatment compliance.
Subsequent maintenance of hair growth can be done with lower concentration. No significant side effects with treatment are
observed in both groups of patients.
Biography
Shivani Dhande is currently a MD Dermatology Resident in Datta Meghe Institute of Medical Sciences (DMIMS), Wardh, India. She is interested in medical, clinical
as well as cosmetic dermatology researches.
Shivani Dhande et al., J Pigment Disord 2017, 4:2 (Suppl)
DOI: 10.4172/2376-0427-C1-002