alexa 99mtc-Depreotide And 99mtc-EDDA/HYNIC-Tyr3-Octreotide S
ISSN: 2161-1459

Journal of Clinical & Experimental Pharmacology
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Research Article

99mtc-Depreotide And 99mtc-EDDA/HYNIC-Tyr3-Octreotide Somatostatin Receptor Scintigraphy in Evaluation of Radiologically Indeterminate Solitary Pulmonary Nodules

Beata E. Chrapko1*, Anna Nocun1, Pawel Rybojad2, Marek Sawicki2, Ewa Poniatowicz-Frasunek1 and Elzbieta Czekajska–Chehab3

1Chair and Department of Nuclear Medicine, Medical University of Lublin, 20-954 Lublin, Jaczewskiego 8, Poland

2Chair and Department of Thoracic Surgery Medical University of Lublin, 20-954 Lublin, Jaczewskiego 8, Poland

3Department of Radiology, Medical University of Lublin, 20-954 Lublin, Jaczewskiego 8, Poland

*Corresponding Author:
Beata E. Chrapko
Chair and Department of Nuclear Medicine
Medical University of Lublin, SPSK4
20-954 Lublin, Jaczewskiego 8, Poland
Tel: +48 1 72 44 339
Fax: +48 1 72 44 339
E-mail: [email protected]

Received Date: October 15, 2011; Accepted Date: December 10, 2011; Published Date: December 14, 2011

Citation: Chrapko BE, Nocun A, Rybojad P, Sawicki M, Poniatowicz-Frasunek E, et al. (2011) 99mtc-Depreotide And 99mtc-EDDA/HYNIC-Tyr3-Octreotide Somatostatin Receptor Scintigraphy in Evaluation of Radiologically Indeterminate Solitary Pulmonary Nodules. Clin Exp Pharmacol 3:130. doi: 10.4172/2161-1459.1000130

Copyright: © 2011 Chrapko BE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The aim of our study was to assess somatostatin receptor scintigraphy (SRS) in evaluation of solitary pulmonary nodules (SPNs). 93 patients with SPNs underwent SRS single photon emission tomography (SPECT) performed with use of one of two somatostatin analogues: 99m Tc-depreotide (49 patients) and 99m Tc-EDDA/HYNIC-Tyr 3 -octreotide (44 patients). 99m Tc-depreotide uptake was true positive (TP) in 37/38 malignant SPNs, and true negative (TN) in 10/11 patients, one false-negative (FN) result and one false-positive (FP) result; the sensitivity, specificity and diagnostic accuracy was 97%, 91% and 96% respectively.

In 99m Tc-EDDA/HYNIC-Tyr 3 -octreotide SRS there were 12 of 20 TP results, 21 of 24 TN results, 8 of 20 were FN and 3 of 24 was FP, resulting in a sensitivity, specificity and diagnostic accuracy of 60%, 88% and 75% respectively. Conclusions : 99m Tc-depreotide SRS in evaluation of SPNs can be recommended as alternative method of diagnosis, while 99m Tc-EDDA/HYNIC-Tyr 3 -octreotide SRS is less effective.

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