alexa A Bioequivalence Comparison of Two Captopril Formulations (25 mg Tablets): An Open-Label, Randomized, Two-Treatment, Two-Way Crossover Study in Healthy Volunteers
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

A Bioequivalence Comparison of Two Captopril Formulations (25 mg Tablets): An Open-Label, Randomized, Two-Treatment, Two-Way Crossover Study in Healthy Volunteers

Chik Z1, Deril NM1*, Didi EMH2, Basu RC1,3, Ratnasingam J3 and Mohamed Z1

1Department of Pharmacology, Faculty of Medicine, University of Malaya Bioequivalence and Testing Centre (UBAT), University of Malaya, Kuala Lumpur, Malaysia

2Department of Pharmacology, Faculty of Medicine, Shimadzu UMMC Centre for Xenobiotic Studies (SUCXeS), University of Malaya, Kuala Lumpur, Malaysia

3Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

*Corresponding Author:
Deril NM
University of Malaya Bioequivalence and Testing Centre (UBAT)
Department of Pharmacology, Faculty of Medicine
University of Malaya, Kuala Lumpur, Malaysia
Tel: 60379676621
E-mail: [email protected]

Received Date: March 12, 2014; Accepted Date: April 28, 2014; Published Date: May 04, 2014

Citation: Chik Z, Deril NM, Didi EMH, Basu RC, Ratnasingam J, et al. (2014) A Bioequivalence Comparison of Two Captopril Formulations (25 mg Tablets): An Open-Label, Randomized, Two-Treatment, Two-Way Crossover Study in Healthy Volunteers. J Bioequiv Availab 6: 080-085. doi: 10.4172/jbb.10000185

Copyright: © 2014 Chik Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

This was an open-label, randomized, 2-treatment, 2-way crossover study with 1 week washout period between the 2 study arms. Healthy volunteers received a 25 mg tablet of the test formulation or 25 mg tablet of the reference formulation. Plasma concentrations of captopril were analyzed using a validated LC-MS/MS method. The mean values for Cmax, Tmax, AUC0–t, and AUC0–∞ with the test formulation of captopril were 235.21 ng/mL, 0.82 hours, 329.25 ng/mL•h, and 337.43 ng/mL•h, respectively; for the reference formulation, the values were 228.28 ng/mL, 0.72 h, 315.87 ng/mL•h, and 323.90 ng/mL•h. For captopril, the 90% CIs for the test formulation/reference formulation ratio for both log Cmax and AUC0–∞ were within the bioequivalence limit of 80% to 125% (81.08–122.78% and 85.19– 117.68%). Both formulations appeared well tolerated in the population studied.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords