A New Preparation Method for Ophthalmic Drug Nanoparticles
Noriaki Nagai and Yoshimasa Ito*
Faculty of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka, 577-8502, Japan
- *Corresponding Author:
- Yoshimasa Ito, PhD
Faculty of Pharmacy, Kinki University
3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502 (Japan)
Tel: +81 6 4307 3640
Fax: +81 6 6730 1394
E-mail: [email protected]
Received date: March 18, 2014; Accepted date: July 30, 2014; Published date: August 07, 2014
Citation: Nagai N, Ito Y (2014) A New Preparation Method for Ophthalmic Drug Nanoparticles. Pharm Anal Acta 5:305. doi:10.4172/2153-2435.1000305
Copyright: © 2014 Nagai N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The most challenging task in ophthalmic therapy has long been the formulation of suitable ocular drug delivery systems due to the unique structure of the eye that restricts entry of the drug molecule at the site of action. Recently, the use of nanotechnology in the ophthalmic field has gained much attention, since nanoparticulate drug delivery is considered to be one of the most promising technologies to overcome poor drug stability and the difficulties in delivering drugs across biological barriers (improvement of bioavailability). This review demonstrates the usefulness of ophthalmic formulations containing drug nanoparticles. Furthermore, in this review, we introduce a new method established in our laboratory for the preparation of drug solid nanoparticles. This information provides significant information that can be used to design further studies aimed at developing less toxic eye drops.