alexa A Retrospective Study on Relation between Cognitive Performance and Lobar Perfusions of Brain in Alzheimer's Dementia using Single Photon Emission Computer Tomography
ISSN: 2168-975X

Brain Disorders & Therapy
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

A Retrospective Study on Relation between Cognitive Performance and Lobar Perfusions of Brain in Alzheimer's Dementia using Single Photon Emission Computer Tomography

Balachandar Rakesh, Srikala Bharath*, Bhavani Shankara Bagepally, Jitender Saini, Shilpa Sadanand, Naveen Donthi, Palanimuthu Thangaraju Sivakumar, Sadanandavally Ratnaswamy Chandra and Mathew Varghese
National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
Corresponding Author : Srikala Bharath, MD, FRC Psych, DCAP
National Institute of Mental Health And Neurosciences
Bangalore, Karnataka, India
Tel: 918026995271
E-mail: [email protected]
Received April 02, 2014; Accepted June 26, 2014; Published July 03, 2014
Citation: Rakesh B, Bharath S, Bagepally BS, Saini J, Sadanand S, et al. (2014) A Retrospective Study on Relation between Cognitive Performance and Lobar Perfusions of Brain in Alzheimer’s Dementia using Single Photon Emission Computer Tomography . Brain Disord Ther 3:135. doi:10.4172/2168-975X.1000135
Copyright: © 2014 Rakesh B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background and objectives: Alzheimer’s disease (AD) is a chronic neurodegenerative condition that progressively affects all cognitive domains. Patients with AD have been documented to have perfusion deficits. We aim to study the perfusion of lobes and its role in cognition among patients with AD. Methodology: Clinical data including cognitive scores on Hindi Mental Status Examination (HMSE) of 16 right handed patients with AD visiting geriatric clinic were recorded. Single Photon Emission Computer Tomography (SPECT) was acquired with standard protocol. Region of interest was applied at each of the frontal, temporal, parietal, occipital, cerebellar lobes to measure the regional perfusion. Results: Patients with AD aged 73.5 ± 8.5 years (6 males) with mean HMSE scores 11.69 ± 5.4 formed the study group. Left temporal lobe perfusion scores emerged as significant (p=0.04) predictor of cognitive scores in patients with AD. We observed a significant difference in perfusion between individual lobes within right hemisphere (p=0.003) and left hemisphere (p=0.009). Conclusion: In this sample of patients with AD we were able to demonstrate the differential pattern of brain perfusion within the intra-hemispheric lobes, possibly due to differential rate of degeneration. We were able to demonstrate a possible association between the left temporal lobe perfusion and cognitive scores in patients with AD.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version