A Review of Novel Formulation Strategies to Enhance Oral Delivery of ZaleplonNarendar Dudhipala*
Department of Pharmaceutics, Vaagdevi Institute of Pharmaceutical Sciences, Warangal, Telangana-506009, India
- Corresponding Author:
- Narendar Dudhipala
Associate Professor, Vaagdevi Institute of Pharmaceutical Sciences
Warangal, Telangana-506009, India
E-mail: [email protected]
Received Date: July 06, 2016; Accepted Date: July 15, 2016; Published Date: July 22, 2016
Citation: Dudhipala N (2016) A Review of Novel Formulation Strategies to Enhance Oral Delivery of Zaleplon. J Bioequiv Availab 8:211-213. doi:10.4172/jbb.1000297
Copyright: © 2016 Dudhipala N. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Zaleplon is a pyrrazolopyrimidine which is recommended for the treatment of insomnia and pentylenetetrazole/ electroshock-induced convulsions is an effective anticonvulsant which potential acts on the GABA receptor. The poor oral bioavailability of zaleplon (~30%) is due to the low solubility which in turn amputates the dissolution of the drug, restricts gastric absorption and first-pass metabolism. It is now withdrawn from the market due to the high dose and inefficient therapeutic activity. This review focuses on the various drug systems of zaleplon such as solid dispersions, self-nanoemulsifying, solid dispersions, proliposomes and solid lipid nanoparticles to enhance the oral bioavailability.