alexa Actuator Performance Comparison by an Integrated Multiv
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

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Research Article

Actuator Performance Comparison by an Integrated Multivariate Approach

Copelli D1,2*, Bodria A1, Magnani I1, Militerno G1, Ponticelli M1, Usberti F1 and Leardi R3

1Chiesi farmaceutici, Largo belloli 11/A, 43122, Parma, Italy

2Department of chemical and geological sciences, Via G. Campi 183, 41125 modena, Italy

3Department of pharmacy, University of genova, Via brigata salerno 13, I-16147 Genova, Italy

*Corresponding Author:
Copelli D
Department of Chemical and Geological Sciences
Via G. Campi 183, 41125 Modena, Italy
Tel: +39 0521279959
E-mail: [email protected]

Received date: May 30, 2016; Accepted date: June 09, 2016; Published date: June 11, 2016

Citation: Copelli D, Bodria A, Magnani I, Militerno G, Ponticelli M, Usberti F, Leardi R (2016) Actuator Performance Comparison by an Integrated Multivariate Approach. Pharm Anal Acta 7:483. doi: 10.4172/2153-2435.1000483

Copyright: © 2016 Copelli D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



During the development of a new Pressurized Metered Dose Inhalers (pMDI) one of the key aspect is to achieve the right performances of the emitted aerosol. Among all variables that can impact the performances, the configuration of the actuator largely affects the atomization process and, as a consequence, the pMDI performances. In order to understand the effect of actuator orifice diameter and actuator sump volume on the final performance, a Face Centered Design has been applied. For each experiment fifteen responses were measured, using a Unit Spray Collector Apparatus (USCA) for the Delivered/Metered Dose and a Next Generation Impactor (NGI) for the Aerodynamic Particle Size Distribution tests. A Principal Component Analysis showed that the NGI responses can be used to demonstrate how the two variables affect the performance of the actuators, while the USCA responses are useless for this purpose. The effect of orifice diameter and sump volume on Fine Particle Mass, Fine Particle Fraction and Mass Median Aerodynamic Diameter, three relevant Aerodynamic Particle Size Distribution responses, were then quantitatively evaluated by Multiple Linear Regression.

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