alexa Additional Antidepressant Pharmacotherapies According to a Neural Network
ISSN: 2168-975X

Brain Disorders & Therapy
Open Access

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Review Article

Additional Antidepressant Pharmacotherapies According to a Neural Network

Felix-Martin Werner1,2* and Rafael Coveñas2
1Higher Vocational School of Elderly Care and Occupational Therapy, Euro Academy, Pößneck, Germany
2Laboratory of Neuroanatomy of the Peptidergic Systems, Institute of Neurosciences of Castilla y León (INCYL), University of Salamanca, Salamanca, Spain
Corresponding Author : Felix-Martin Werner
Professor, University of Salamanca
Instituto de Neurociencias de Castilla y León (INCYL)
Laboratorio de Neuroanatomía de los Sistemas Peptidérgicos (Lab. 14)
c/ Pintor Fernando Gallego 1
37007-Salamanca, Spain
Tel: +3492329 44 00
Fax: +34923294549
E-mail: [email protected]
Received December 23, 2015; Accepted January 19, 2016; Published January 22, 2016
Citation: Werner F, Coveñas R (2016) Additional Antidepressant Pharmacotherapies According to a Neural Network. Brain Disord Ther 5:203. doi:10.4172/2168-975X.1000203
Copyright: © 2016 Werner F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Major depression, a frequent psychiatric disease, is associated with neurotransmitter alterations in the midbrain, hypothalamus and hippocampus. Deficiency of postsynaptic excitatory neurotransmitters such as dopamine, noradrenaline and serotonin and a surplus of presynaptic inhibitory neurotransmitters such as GABA and glutamate (mainly a postsynaptic excitatory and partly a presynaptic inhibitory neurotransmitter), can be found in the involved brain regions. However, neuropeptide alterations (galanin, neuropeptide Y, substance P) also play an important role in its pathogenesis. A neural network is described, including the alterations of neuroactive substances at specific subreceptors. Currently, major depression is treated with monoamine reuptake inhibitors. An additional therapeutic option could be the administration of antagonists of presynaptic inhibitory neurotransmitters or the administration of agonists/antagonists of neuropeptides.

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