alexa Adverse Drug Reactions to Antiretroviral Therapy (ART): Prospective Study in HIV Infected Adults in Sikasso (Mali)
ISSN: 2329-6887

Journal of Pharmacovigilance
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Research Article

Adverse Drug Reactions to Antiretroviral Therapy (ART): Prospective Study in HIV Infected Adults in Sikasso (Mali)

Aboubacar Alassane Oumar*, Amadou Abdoulaye, Mamoudou Maiga, Younoussa Sidibé, Yacouba Cissoko, Issa Konaté, Maimouna Diarra, Fanta Sangho, Jean Paul Dembélé, Paul M Tulkens and Sounkalo Dao

University of Sciences, Techniques and Technology Bamako, Bamako, Mali

*Corresponding Author:
Aboubacar Alassane Oumar
University of Sciences
Techniques and Technology Bamako
Bamako, Mali
Tel: 00223 20226786
E-mail: [email protected]

Received Date: April 06, 2017; Accepted Date: April 19, 2017; Published Date: April 27, 2017

Citation: Oumar AA, Abdoulaye A, Maiga M, Sidibé Y, Cissoko Y, et al. (2017) Adverse Drug Reactions to Antiretroviral Therapy (ART): Prospective Study in HIV Infected Adults in Sikasso (Mali). J Pharmacovigil 5:228. doi: 10.4172/2329-6887.1000228

Copyright: © 2017 Oumar AA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objective: The purpose of this study was to evaluate the adverse effects of Antiretroviral Therapy (ART) in adult HIV-infected patients in decentralized setting of Sikasso, in Mali. Methods: This is a proactive study that took place from 2 January 2011 to 30 December 2012 at the Hospital of Sikasso (Department of Medicine). HIV-infected adult patients who have started ART at least 3 months before were included in this study to monitor the laboratory and clinical Adverse Drug Reactions (ADR) for at least 6 months. The WHO classification of adverse drug reactions has been used to investigate the causality of antiretrovirals. Results: Women were the most represented with 58% of the cases. The most represented age range was 26-47 years with 73.6%. Of the 178 patients enrolled, 61.2% had an ADR. ADR were neurological (40.4%), digestive (35.8%), cutaneous (18.3%) and hematological (5.5%). Stavudine was the most incriminated molecule, in 24.8% of the cases. The WHO grade 4 classification of ART toxicity was represented in 3.4% of the cases. The WHO causality score of “certain” was found in 29.8% of the cases. Conclusion: Adverse effects of Antiretrovirals are frequent and could be life-threatening in short and long terms. Regular follow-up of patients receiving these triple therapies, and the associated complications, is essential. We recommend active surveillance of antiretroviral therapy to strengthen Pharmacovigilance in Mali.

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