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Ameliorative Role of Dietary Supplemented Conjugated Linolenic Acid against Nicotine-Induced Toxicity in Rats | OMICS International | Abstract
ISSN : 2153-2435

Pharmaceutica Analytica Acta
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Research Article

Ameliorative Role of Dietary Supplemented Conjugated Linolenic Acid against Nicotine-Induced Toxicity in Rats

Krishna Chattopadhyay1, Moumita Maity2, Satyam Banerjee2 and Brajadulal Chattopadhyay2*

1Department of Chemical Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India

2Department of Physics, Jadavpur University, 188 Raja S.C. Mallik Road, Kolkata 700032, India

*Corresponding Author:
Brajadulal Chattopadhyay
Department of Physics
Jadavpur University
188 Raja S.C. Mallik Road
Kolkata 700032, India
Tel: +91-9433343917
Fax: +91-33-24138917
E-mail: [email protected]

Received date: August 13, 2012; Accepted date: November 05, 2012; Published date: November 07, 2012

Citation: Chattopadhyay K, Maity M, Banerjee S, Chattopadhyay B (2012) Ameliorative Role of Dietary Supplemented Conjugated Linolenic Acid against Nicotine-Induced Toxicity in Rats. Pharmaceut Anal Acta 3:182. doi: 10.4172/2153-2435.1000182

Copyright: © 2012 Chattopadhyay K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Increasing consumption of tobacco in different forms harms almost every organs of our body. Nicotine is the culprit for various physiological repercussions arouse due to the uptake of tobacco. As nutritional status alters the actions, potencies and detoxification of toxicants, the present study was undertaken to evaluate the natural antioxidant efficacy of conjugated linolenic acid present in Karalla seed against nicotine-induced toxicity. Experiments were conducted on male albino rats (120–130 g body weight) by injecting nicotine tartarate (3.5 mg/kg body wt. /day for 15 days) subcutaneously and thereby simultaneously supplementing conjugated linolenic acid (0.5 and 1.0%) to their diets. Nicotine significantly altered serum and liver lipid profiles, lipid peroxidation and activities of antioxidant enzymes. It caused significant decrease of DNA contents (P<0.01) and DNA damage (P<0.001) of liver tissue. Conjugated linolenic acid has the ability to bind with DNA and protein similar to nicotine and thereby ameliorates nicotine-induced toxicity in rats. Thus intake of Karalla that contains conjugated linolenic in its seeds, in our daily diet can effectively attenuate nicotine-induced cellular and genetic damages.


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