alexa Anticancer Activities of Resveratrol in Colorectal Cancer
ISSN: 0974-8369

Biology and Medicine
Open Access

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Review Article

Anticancer Activities of Resveratrol in Colorectal Cancer

Evelien Schaafsma1,2, Tze-chen Hsieh1, Barbara B Doonan1, John T Pinto1 and Joseph M Wu1*

1Departments of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA

2Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA

*Corresponding Author:
Joseph M Wu
Department of Biochemistry and Molecular Biology
Basic Sciences Building, New York Medical College
15 Dana Road, Valhalla, NY 10595, USA
Tel: (914)-594-4891
Fax: (914)-594-4058
E-mail: [email protected]

Received Date: July 01, 2016; Accepted Date: July 22, 2016; Published Date: July 27, 2016

Citation: Schaafsma E, Hsieh T, Doonan BB, Pinto JT, Wu JM (2016) Anticancer Activities of Resveratrol in Colorectal Cancer. Biol Med (Aligarh) 8:317. doi:10.4172/0974-8369.1000317

Copyright: © 2016 Schaafsma E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a dietary polyphenolic phytochemical that has demonstrated health benefits such as cardioprotection, the prevention of neurodegeneration and chemoprevention. Resveratrol has shown great potential in the prevention and treatment of carcinomas and clinical trials support resveratrol as anticancer compound in colorectal carcinoma. Colorectal cancer remains a major cause of cancer-related deaths for both men and women in industrialized countries. Because of this widespread prevalence, identifying major risk factors and initiating colorectal screening procedures provide the distinct advantage for recognizing early disease and addressing treatable forms of CRC. Epidemiological studies of fruit and vegetable consumption in relationship to developing CRC have led to the notion that safe and inexpensive chemopreventive agents might be a valuable tool in diminishing the morbidity and mortality of CRC. While clinical trials and in vivo data show positive effects of resveratrol in CRC, the mechanism of action is relatively unclear. In this review, we will evaluate the current literature on the actions of resveratrol in CRC and provide a more mechanistic view of resveratrol in relationship with CRC.

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