alexa Antidepressants in Pregnancy and Autism Spectrum Disorder: A Systematic Review
ISSN: 2378-5756

Journal of Psychiatry
Open Access

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Review Article

Antidepressants in Pregnancy and Autism Spectrum Disorder: A Systematic Review

Antônio Carlos C Freire1*, Camila CM de Oliveira2 and Milena Pereira Pondé3

1Escola Baiana de Medicina e Saúde Pública, Hospital Juliano Moreira, Salvador, Bahia, Brazil

2Escola Baiana de Medicina e Saúde Pública (EBMSP), EBMSP Research Group in Endocrinopathies during Pregnancy, Maternidade José Maria Magalhães Neto, Salvador, Bahia, Brazil

3Escola Baiana de Medicina e Saúde Pública, EBMSP Interdisciplinary Laboratory of Research in Autism, Salvador, Bahia, Brazil

*Corresponding Author:
Antônio Carlos Cruz Freire
Escola Baiana de Medicina e Saúde Pública
Hospital Juliano Moreira
Salvador, Bahia, Brazil
Tel: +55 71 3235-9070
E-mail: [email protected]

Received Date: October 24, 2016; Accepted Date: November 23, 2016; Published Date: November 30, 2016

Citation: Freire ACC, Oliveira CCD, Pondé MP (2016) Antidepressants in Pregnancy and Autism Spectrum Disorder: A Systematic Review. J Psychiatry 19: 392. doi: 10.4172/2378-5756.1000392

Copyright: © 2016 C Freire ACC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited



Purpose: To determine the risk of autism spectrum disorder (ASD) in children following antidepressant use in pregnancy. Methods: A systematic review using the CAPES platform for the January 2005 to May 2015 period. The descriptors used were (antidepressant) and (pregnancy) and (autism). Articles were selected based on preestablished inclusion/exclusion criteria, with quality evaluated using the STROBE checklist. Results: Six articles were evaluated, with five favoring some form of association between antidepressant use in pregnancy and ASD in the child. In one paper, this association was found only with boys, while another identified the risk in children exposed to maternal depressive symptoms with no use of selective serotonin reuptake inhibitors. Conclusion: Results show that in addition to the multiple factors linked to antidepressant use in pregnancy and child development, factors other than drug exposure may play a role in the development of ASD. Further studies are required to clarify this issue.


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