alexa ASS and SULT2A1 are Novel and Sensitive Biomarkers of Acute Hepatic Injury-A Comparative Study in Animal Models
ISSN: 2167-0889

Journal of Liver
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Research Article

ASS and SULT2A1 are Novel and Sensitive Biomarkers of Acute Hepatic Injury-A Comparative Study in Animal Models

Victor Prima1*, Mengde Cao1 and Stanislav I Svetlov1,2*
1Banyan Laboratories, Inc., Alachua, FL, USA
2Department of Medicine, University of Florida, Gainesville, FL, USA
Corresponding Authors: Stanislav I Svetlov
Banyan Laboratories, Inc
12085 Research Drive, Alachua, FL 32615, USA
Tel: (386)518-6756
E-mail: [email protected]
  Victor Prima
Department of Medicine, University of Florida
Gainesville, FL, USA
Tel: (386)518-6761
E-mail: [email protected]
Received November 27, 2012; Accepted January 05, 2013; Published January 10, 2013
Citation: Prima V, Cao M, I Svetlov S (2013) ASS and SULT2A1 are Novel and Sensitive Biomarkers of Acute Hepatic Injury-A Comparative Study in Animal Models. J Liver 2: 115. doi: 10.4172/2167-0889.1000115
Copyright: © 2013 Prima V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Liver and kidney damage associated with polytrauma, endotoxic shock/sepsis, and organ transplantation, are among the leading causes of the multiple organ failure. Development of novel sensitive biomarkers that detect early stages of liver and kidney injury is vital for the effective diagnostics and treatment of these life-threatening conditions. Previously, we identified several hepatic proteins, including Argininosuccinate Synthase (ASS) and sulfotransferases which were degraded in the liver and rapidly released into circulation during Ischemia/Reperfusion (I/R) injury. Here we compared sensitivity and specificity of the newly developed sandwich ELISA assays for ASS and the sulfotransferase isoform SULT2A1 with the standard clinical liver and kidney tests Alanine Aminotransferase (ALT) and Aspartate Transaminase (AST) in various pre-clinical models of acute injury. Our data suggest that ASS and SULT2A1 have superior characteristics for liver and kidney health assessment in endotoxemia, Ischemia/ Reperfusion (I/R), chemical and drug-induced liver injury and may be of high potential value for clinical applications.

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