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ISSN: 2378-5756

Journal of Psychiatry
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Review Article

Assessment of Association between Schizophrenia and Chlamydiaceae Using Hill Criteria

Bekir Kocazeybek* and Fatma Kalayci

 

Department of Microbiology and Clinical Microbiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey

*Corresponding Author:
Bekir Kocazeybek
Department of Microbiology and
Clinical Microbiology, Cerrahpasa
Medical Faculty, Basic Science Building
Floor 2, Fatih, Ä°stanbul, Turkey
Tel: 00-90-532-6168150
Fax: 00-90-212-6322122
E-mail: [email protected]

Received Date: January 10, 2015; Accepted Date: February 17, 2015; Published Date: February 24, 2015

Citation: Kocazeybek B, Kalayci F (2015) Assessment of Association between Schizophrenia and Chlamydiaceae Using Hill Criteria. J Psychiatry 18:250. doi: 10.4172/Psychiatry.1000250

Copyright: © 2015 Kocazeybek B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Abstract

Schizophrenia is a complex chronic neuropsychiatric disorder of the central nervous system with worldwide prevalence. The disease is thought to have multiple etiologies, including infections, genetic predisposition, and other environmental factors. There is increasing evidence pointing to a close association between chlamydial infections and schizophrenia. Here, we review the data available in the literature on the detection of bacterial species in the family Chlamydiaceae in schizophrenia and critically analyze the association and causal relationship between Chlamydiaceae and schizophrenia following the established criteria of Hill. This analysis demonstrates a probable causal relationship between Chlamydiaceae and schizophrenia. The identification of microbial agents associated with the etiopathogenesis of schizophrenia may provide new insight into the diagnosis, treatment and prevention of the disorder.

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