alexa Association of Vitamin D Level and Subclinical Coronary Artery Disease | OMICS International
ISSN: 2161-0509

Journal of Nutritional Disorders & Therapy
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Research Article

Association of Vitamin D Level and Subclinical Coronary Artery Disease

Anas Alani1, Sirous Darabian2, Yanting Luo2, Rine Nakanishi2, Omar Al-Juboori2, Suguru Matsumoto2, Negin Nezarat2, Matthew J Budoff2* and Ronald P Karlsberg3,4

1Department of Cardiology, University of Florida- Gainesville, FL, USA

2Department of Biomedical, Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA, USA

3Department of Cardiology, The Cardiovascular Research Foundation of Southern California, Beverly Hills, CA, USA

4Department of Cardiology, Cedars Sinai Heart Institute, Los Angeles, CA, USA

*Corresponding Author:
Matthew J Budoff
Los Angeles Biomedical Research Institute at Harbor-UCLA
Torrance, CA, USA
Tel: (310) 222-4107
Fax: (310) 782-9652
E-mail: [email protected]

Received date: January 13, 2016; Accepted date: January 23, 2016; Published date: January 28, 2016

Citation: Alani A, Darabian S, Luo Y, Nakanishi R, Al-Juboori O, et al. (2016) Association of Vitamin D Level and Subclinical Coronary Artery Disease. J Nutr Disorders Ther 6:181. doi:10.4172/2161- 0509.1000181

Copyright: © 2016 Alani A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited


Background: The role of vitamin D level in subclinical atherosclerosis remains controversial. We aimed to investigate the relationship between vitamin D level and coronary artery calcium score (CACS).

Patients methods: We investigated 303 consecutive patients referred to an outpatient clinic for CACS. The 25-hydroxy vitamin D [25(OH) D] levels were checked within three months of CACS evaluation. Vitamin D levels of <30 and <20 ng/mL were used as thresholds of vitamin D insufficiency and deficiency, respectively. The correlation between CACS and vitamin D was assessed. Unadjusted and covariate-adjusted logistic regression analyses were used to predict positive CACS.

Results: The mean age in this study is 61.8 ± 11.8 years (39.9% female). The majority of patients enrolled were Caucasian (87.4%). Median (interquartile range) serum 25(OH) D concentration was 30.0 (23.0, 39.0) ng/ml. Vitamin D was insufficient (<30 ng/ml) in 47.2% and deficient (<20 ng/mL) in 14.9% of the sample. Positive CACS (CACS>0) was prevalent in 206 (68%) participants. In the unadjusted model, the 25 (OH) D levels were not associated with the prevalence of CACS among all cases or among patients with positive CACS. Logistic regression models, after controlling for risk factors, did not change the results. In addition, among the 206 participants with prevalent CACS, 25 (OH) D levels were not associated with CACS severity.

Conclusions: Our single centre retrospective study in a population with low prevalence of vitamin D deficiency failed to find a significant relation between 25(OH) D level and CACS even when adjusted for risk factors.


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