alexa Beyond SNPs and CNV: Pharmacogenomics of Polymorphic Ta
ISSN: 2153-0645

Journal of Pharmacogenomics & Pharmacoproteomics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Beyond SNPs and CNV: Pharmacogenomics of Polymorphic Tandem Repeats

Evgeny Krynetskiy*

School of Pharmacy, Temple University, PA, USA

*Corresponding Author:
Evgeny Krynetskiy
School of Pharmacy
Temple University
PA 19140, USA
Tel: 215-707-4257
Fax: 215-707-5620
E-mail: [email protected]

Received Date: May 18, 2017; Accepted Date: June 20, 2017; Published Date: June 27, 2017

Citation: Krynetskiy E (2017) Beyond SNPs and CNV: Pharmacogenomics of Polymorphic Tandem Repeats. J Pharmacogenomics Pharmacoproteomics 8:170. doi: 10.4172/2153-0645.1000170

Copyright: © 2017 Krynetskiy E. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Polymorphic Short Tandem Repeats (STR) emerged as a separate class of genetic mutation, which together with Single Nucleotide Polymorphisms (SNPs) and Copy Number Variations (CNVs) can explain variability in response to pharmacotherapy. STR draws interest in pharmacogenomics research because of their prevalence in the human genome, and their putative functional role as regulators of gene expression. Depending on the search algorithm, there are approximately 700,000–1,000,000 STR loci with 2-6 bp long motifs in the human reference genome. STR is non-randomly distributed across Untranslated Regions (UTRs), protein-coding sequences, and introns, and is overrepresented in the promoter regions of the human genes. The functional role of STR has been demonstrated by effects on gene expression, splicing, protein sequence, and association with pathogenic effects. An intrinsic property of STR is the high rate of mutation by expansion or contraction in the number of repeat units. Variation in the length of STR plays an important role in modulating gene expression, and STR is likely to be general regulatory elements which attenuate expression of multiple genes. Elucidating the effects of STR on gene expression may in part explain variability in drug response, something that cannot be achieved by focusing analysis exclusively on SNPs or CNV. This review summarizes the role of polymorphic STR in clinical manifestations including response to pharmacotherapy.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords