alexa Breast Cancer is Usually Described as Uncontrolled Cellular Growth However Recent Research Suggests That is not Accurate - At Least before Primary Surgery
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Breast Cancer is Usually Described as Uncontrolled Cellular Growth However Recent Research Suggests That is not Accurate - At Least before Primary Surgery

Michael Retsky*

Michael Retsky, BioMedical Imaging Laboratory, Harvard School of Public Health, BLDG I, Rm 1311, 665 Huntington, Ave., Boston, MA 02115, USA

*Corresponding Author:
Michael Retsky
BioMedical Imaging Laboratory
Harvard School of Public Health
BLDG I, Rm 1311, 665 Huntington
Ave., Boston, MA 02115, USA
Tel: 617-432-3472
E-mail: [email protected]

Received Date: November 14, 2011; Accepted Date: December 03, 2011; Published Date: December 05, 2011

Citation: Retsky M (2011) Breast Cancer is Usually Described as Uncontrolled Cellular Growth However Recent Research Suggests That is not Accurate – At Least before Primary Surgery. J Bioequiv Availab S1: 009. doi: 10.4172/jbb.S1-009

Copyright: © 2011 Retsky M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



In 1993 my colleagues and I were confronted with data that showed a bimodal pattern for relapse after surgery to remove primary breast cancer. This was quite unexpected since tumor growth was considered to be steady and continuous. Starting with a simple tumor growth model we proceeded to develop a computer simulation that might explain these data. We determined that over half of all relapses in breast cancer are accelerated by something related to primary surgery. These findings have also been used to explain a number of clinical features of breast cancer that were previously thought to be unrelated. This information has been published several times and for full discussion the reader is referred to our reviews. What has not been discussed previously is why we felt confident that these data were of sufficient high quality that we could make such dramatic conclusions. That is, there were literally hundreds of previous reports of breast cancer relapse that did not cite a bimodal relapse. Why is one found in the Milan database and why did we feel confident enough to make strong and counterintuitive conclusions? As final remarks, at risk of pontification, the cancer research community is advised that instead of cancer being categorized as uncontrolled cellular growth, it is mostly quiescent at least before primary surgery. The cancer research community’s emphasis on discovering cancer growth pathways and how to block these pathways may be misdirected. Thus it is recommended that cancer research be redirected towards understanding why and how cancer is restrained before surgery and how that state may be retained for indefinite periods of time to avoid relapse.

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version