Cardiovascular Applications of Stem Cell Therapy
Soheil Sadri1, Ramesh Mazhari2, Maziar Sadri2, Nahal Konjedi1, and Palak Shah2*
1Division of Genomic Medicine, USA
2Division of Cardiology, George Washington University, Washington DC, USA
- Corresponding Author:
- Palak Shah
MD, Division of Cardiology
Medical Faculty Associates, Suite 4-417
2150 Pennsylvania Avenue NW, Washington DC 20037
E-mail: [email protected]
Received Date: September 15, 2011; Accepted Date: November 02, 2011; Published Date: November 04, 2011
Citation: Sadri S, Mazhari R, Sadri M, Konjedi N, Shah P, (2011) Cardiovascular Applications of Stem Cell Therapy. J Stem Cell Res Ther S1:003. doi:10.4172/2157-7633.S1-003
Copyright: © 2011 Sadri S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Despite remarkable progress in medical and surgical therapy for heart disease, congestive heart failure (CHF) and coronary artery disease (CAD) are leading causes of morbidity and mortality in the United States. Although implantation of a left ventricular assist device has recently emerged as a promising therapy for CHF, no other therapy holds as much promise for the treatment of patients suffering from cardiovascular disease other than cardiac regeneration. In this regard, there are substantial pre-clinical and clinical studies that have elucidated the safety and efficacy of cardiac stem cell-based therapy using a variety of cell lines to promote regeneration of the heart. In spite of promising results in both animal and human studies, the exact fate of these administered stem cells within the human heart is poorly understood as is the mechanism by which they promote myocardial recovery and regeneration. These limitations of our current knowledge base can be considered a critical issue limiting widespread application of stem cell-based therapy.