alexa Comparative Study of Anti-Hyperglycemic and Anti-Hyperlipidemic Effects of Honey, Coccinia cordifolia and Hilsha Fish Oil in Streptozotocin Induced Diabetic Rats | Abstract
ISSN: 0974-8369

Biology and Medicine
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Research Article

Comparative Study of Anti-Hyperglycemic and Anti-Hyperlipidemic Effects of Honey, Coccinia cordifolia and Hilsha Fish Oil in Streptozotocin Induced Diabetic Rats

Rahman MS1, Asaduzzaman M1, Munira S1, Begum MM2, Rahman MM1, Hasan M3, Khatun A4, Maniruzzaman M5, Islam M1, Khan MHK1, Rahman M1, Karim MR1 and Islam MA1*

1Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi-6205, Bangladesh

2Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Bangladesh

3Department of Biophysical Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-Ku, Kyoto 607-8414, Japan

4Department of Pharmacology, Kyoto Pharmaceutical University, Japan

5Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh

*Corresponding Author:
Mohammad Amirul Islam
Professor, Department of Biochemistry and Molecular Biology
University of Rajshahi, Rajshahi-6205, Bangladesh
Tel: +88-0721 750049/4109
Fax: +88-0721-750064
E-mail: [email protected]

Received: November 11, 2015; Accepted: January 28, 2016; Published: February 02, 2016

Citation: Rahman MS, Asaduzzaman M, Munira S, Begum MM, Rahman MM, et al. (2016) Comparative Study of Anti-Hyperglycemic and Anti- Hyperlipidemic Effects of Honey, Coccinia cordifolia and Hilsha Fish Oil in Streptozotocin Induced Diabetic Rats. Biol Med (Aligarh) 8:272. doi:10.4172/0974-8369.1000272

Copyright: © 2016 Rahman MS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Abstract

This study was aimed to evaluate the efficacy of Honey, Coccinia cordifolia (Locally known as Telakucha) leaves and Hilsha fish oil as hypoglycemic and hypolipedemic agents in diabetic condition. The leaves were initially under shade, grinded to powder, extracted with ethanol and filtered through Whatmann filter paper. The filtrate was concentrated by rotatory evaporator and stored at 4°C. The experimental rats were divided into six groups (n=6). Diabetes mellitus (DM) was induced by single intraperitoneal injection (65 mg/kg BW) of freshly prepared streptozotocin hydrate solution in 0.9% saline solution. Hyperlipidemic was induced by mixture of cholesterol (1.5 %) and cholic acid (0.5%) with diet of rats. At the end of the treatment, the blood glucose level and lipid profile was measured by using commercial kits. It was observed that honey, plant leaves extract and Hilsha fish oil (HFO) have potential hypoglycemic effect as it significantly (p<0.001) decrease blood glucose level compared to diabetic control (DC) group. The serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT) and C- reactive protein (CRP) were also decreased significantly (p<0.001). An indicative antilipidemic effect was also observed as total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL) showed significant (p<0.05) decrease whereas HDL showed significant increase (p<0.001) by the treatment compared to DC group. From the above observations it can be concluded that the honey, C. cordifolia leaves extract and HFO have an effective therapeutic value in the treatment of DM and in the management of associated cardiovascular and hepatic complications.

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