alexa Computational Analysis on the Role of GPM6A in Human Thyroid Cancer
ISSN: 2153-0602

Journal of Data Mining in Genomics & Proteomics
Open Access

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Research Article

Computational Analysis on the Role of GPM6A in Human Thyroid Cancer

Zoya Khalid1, Sheema Sameen1, Shaukat I Malik2* and Shehzad S1

1Department of Environmental Sciences, International Islamic University, Islamabad, Pakistan

2Department of Bioinformatics, Muhammad Ali Jinnah University, Islamabad, Pakistan

*Corresponding Author:
Shaukat I Malik
Department of Bioinformatics
Muhammad Ali Jinnah University, Islamabad, Pakistan
E-mail: [email protected]

Received Date: October 15, 2011; Accepted Date: January 17, 2012; Published Date: January 20, 2012

Citation: Khalid Z, Sameen S, Malik SI, Shehzad S (2012) Computational Analysis on the Role of GPM6A in Human Thyroid Cancer. J Data Mining in Genom Proteomics 3:114. doi: 10.4172/2153-0602.1000114

Copyright: © 2012 Khalid Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Thyroid cancer is one of the major cancers around the world. In this study the whole thyroid genome is systematically scanned in order to hit those molecular targets which are highly associated with thyroid cancer. To achieve this goal bioinformatics methodologies are combined. These include the high throughput microarray analysis combined with Serial analysis of gene expression. The results obtained revealed Glycoprotein M6A (GPM6A) as a novel associated gene marker. It belongs to the glycoprotein’s family which plays a major role in cell migration and also known as the major contributors in tumor formation. Moreover the biological pathway of GPM6A is not yet been defined. In this study by assessing the whole biological mechanism the pathway is also inferred .This new drug target will help the biologists in finding the early diagnosis and better treatment for the thyroid cancer patients.

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