alexa Cooperation of Mast Cells and Basophils in Allergy | OMICS International | Abstract
ISSN: 2155-6121

Journal of Allergy & Therapy
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Review Article

Cooperation of Mast Cells and Basophils in Allergy

Enrico Crivellato1 and Domenico Ribatti2*

1Department of Experimental and Clinical Medicine, Anatomy Section, University of Udine Medical School, Italy

2Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Italy

*Corresponding Author:
Domenico Ribatti
Department of Basic Medical Sciences
Neurosciences and Sensory Organs
University of Bari Medical School
Piazza G. Cesare, 11, Policlinico
70124 Bari, Italy
Tel: 39-080-5478326
Fax: 39-080-5478310
E-mail: [email protected]

Received date: March 22, 2013; Accepted date: May 22, 2013; Published date: May 29, 2013

Citation: Crivellato E, Ribatti D (2013) Cooperation of Mast Cells and Basophils in Allergy. J Allergy Ther 4:135. doi: 10.4172/2155-6121.1000135

Copyright: © 2013 Crivellato E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Mast cells and basophils are granulated cells, which share similar phenotypic and functional properties. They express complementary and partially overlapping roles in acquired and innate immunity, including both effector and regulatory activities, but they also display important distinctive features as to developmental lineage, mediator content, and function. They cooperate in expanding and/or modulating inflammation as well as in mediating subsequent tissue repair. Mast cells release in the inflammatory scenario a series of potent proangiogenic molecules that stimulate vessel sprouting and new vessel formation. Recent data suggest that basophils may also play a role in inflammation-related angiogenesis, principally but not exclusively through the expression of several forms of VEGF and their receptors. This review focuses on the potential cooperative link between mast cells and basophils in promoting angiogenesis during allergic inflammation. We discuss the multifaceted roles of mast cells and basophils in the inflammatory setting during allergic diseases and whether these cells can be both source and target cells for proangiogenic mediators.

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