Journal of Tropical Diseases & Public Health

Abstract

Current Concepts in the Immunological Diagnosis of H. pylori in Basrah Pediatric Oncology Unit

Amer Naes Amer, Janan G. Hassan and Ihsan Edan Al-Saimary

Objective: The concentration of Immunological markers (IgG, IgM, IgA, C3 and C4) were determine for children with cancer in basrah pediatric oncology unit during 2009.

Methods: A prospective comparative case-control study was carried out over 7 months from 12^th of March 2009 to 26^th of September 2009, the study included 29 children (20 male and 9 female) with different types of malignancies. Investigations were done for H. pylori and one step diagnostic test (which detect the antigen for H. pylori) and determine the concentration of (IgG, IgM, IgA, C3, C4).

Results: There is statistically significant higher percentage of patient group having H. pylori comparing to control group with PH. pylori in relation to immunological status of studied patients , there was a significant association between H. pylori and high IgG with a mean (715.01) for H. pylori positive patient and mean (553.20) for H. pylori negative patient, PH. pylori and high IgA with a mean (94.29) for H. pylori positive patient and mean (58.54) for H. pylori negative patient PH. pylori and low C4 with a mean (47.31) for H. pylori positive patient and mean (79.57) for H. pylori negative patient and P

Conclusion: The study evidenced strong relationships between frequency of H. pylori and immune compromised Childs according to immunological investigation.

Note: This work is part of thesis submitted by the first author to the scientific council of pediatrics in partial fulfillment for the degree of Fellowship of the Iraqi Board for Medical Specializations in Pediatrics