alexa Current Issues on Bioavailability and Bioequivalence De
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Current Issues on Bioavailability and Bioequivalence Determination

Chyung S. Cook*

Baxter Healthcare, USA

*Corresponding Author:
Chyung S. Cook, Ph.D.
25212 Illinois Route 120
Round Lake, IL 60073, USA
Tel: (847) 270-5319
E-mail: [email protected]

Received Date: August 30, 2011; Accepted Date: September 22, 2011; Published Date: September 24, 2011

Citation: Cook CS (2011) Current Issues on Bioavailability and Bioequivalence Determination. J Bioequiv Availab S1: 003. doi: 10.4172/jbb.S1-003

Copyright: © 2011 Cook CS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Methodologies for determining bioavailability and bioequivalence of endogenous compounds and macromolecules such as polymers are different from that of small exogenous compounds. In many cases, bioavailability and bioequivalence guidelines for exogenous molecules may not be appropriate for endogenous compounds. A common approach of baseline subtraction for endogenous materials is arguable in some cases, since levels of endogenous materials are highly variable during an experimental period. For polymers molecular weight distribution may be different among the materials from different manufactures and/or different manufacturing processes. These issues are addressed along with following issues regarding bioavailability/ bioequivalence determination: use of pharmacokinetic vs. pharmacodynamic parameters, use of a chiral assay vs. total assay for racemic drugs, and total vs. free concentration assays for drugs that exhibit concentration-dependent plasma protein binding, and for liposome/protein encapsulated formulations.

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version