Current Updates in the Genetic Polymorphisms of Human Organic Anion Transporters (OATs)Zhen Li1,§, Ping Hei Lam1,§, Ling Zhu2, Ke Wang3 and Fanfan Zhou1*
- *Corresponding Author:
- Fanfan Zhou
Pharmacogenomics and Drug Development Laboratory
Faculty of Pharmacy
The University of Sydney, Room 104
Level 1, Medical Foundation Building (K25) 92 Parramatta Road
Camperdown, NSW 2006, Australia
Tel: (61) 02-9036-3015
E-mail: [email protected]
Received date: October 01, 2012; Accepted date: October 02, 2012; Published date: October 02, 2012
Citation: Li Z, Lam PH, Zhu L, Wang K, Zhou F (2012) Current Updates in the Genetic Polymorphisms of Human Organic Anion Transporters (OATs). J Pharmacogenomics Pharmacoproteomics 3:e127. doi: 10.4172/2153-0645.1000e127
Copyright: © 2012 Li Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The Organic Anion Transporters (OATs) are a family of important membrane proteins responsible for the
absorption, distribution and excretion of a wide range of substances, including many clinically important drugs.Therefore, the function of OATs is the key determinant of drug response in human. Human genetic polymorphisms often result in the functional alternation of OATs, which in consequence, leads to the interpatient variation of therapies. In this review, we summarize the current findings about OATs, with a focus on the genetic polymorphisms and their influence on transporter function and drug performance, the information of which is critical in elucidating the essential roles of OATs played in body, as well as forming the basis of future therapeutic optimization in individuals.