alexa Delusional Misidentification Syndrome with Response to
ISSN: 2329-8847

Journal of Aging Science
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Case Report

Delusional Misidentification Syndrome with Response to Donepezil and Behavioral Intervention in a Patient with Dementia

Muhammad Ubaid Hafeez1#, Katherine T. Mun2#, Haris Kamal1 and Kinga Szigeti1*

1Department of Neurology, The State University of New York at Buffalo, USA

2Department of Psychiatry, The State University of New York at Buffalo, USA

#The first two authors contributed equally to the manuscript

*Corresponding Author:
Kinga Szigeti
Department of Neurology, University at Buffalo
100 High Street, E2, Buffalo
New York, 14203, USA
Tel: (716) 859-3539
E-mail: [email protected]

Received date: June 11, 2017; Accepted date: July 17, 2017; Published date: July 21, 2017

Citation: Hafeez MU, Mun KT, Kamal H, Szigeti K (2017) Delusional Misidentification Syndrome with Response to Donepezil and Behavioral Intervention in a Patient with Dementia. J Aging Sci 5:181. doi:10.4172/2329-8847.1000181

Copyright: © 2017 Hafeez MU, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Introduction: Delusional Misidentification Syndrome (DMS) encompasses a group of disorders in which a person persistently believes the identity of people, places, or objects are altered. Historically, described in psychotic disorders, DMS prevalence is 15.8% in Alzheimer's disease (AD) and 16.6% in dementia with Lewy bodies (DLB). We present a case of DMS in a patient with dementia that incorporates elements of mirrored self-misidentification and phantom boarder syndrome and therapeutic response to a combination of a behavioral intervention and donepezil.

Case: 75-year-old white female presented with a four months history of DMS and visual hallucinations. Patient perceived her own reflection in picture glass as an older lady who was trying to steal her "boyfriends." Her "boyfriends" were three pictures of soldiers in her apartment. MMSE was 27/30 (WORLD) and 23/30 (Serial 7s). MRI showed biparietal and right hippocampal atrophy. NPT showed impaired language, spatial abilities, memory, and executive control. She scored <1 percentile on category word fluency, judgement of line orientation, raw complex figures and Beery VMI. Patient was diagnosed with probable AD, using NINCDS-ADRDA and findings on neuropsychological testing (NPT) and MRI. DLB was excluded using McKeith's criteria. After a failed trial of risperidone, she received donepezil and family was instructed to remove photographs. MMSE stable with resolution of the mirrored selfmisidentification at 4 months follow up.

Conclusion: Patient's poor response to risperidone is consistent with previous studies suggesting limitations of antipsychotic treatment for psychotic symptoms in AD. Removal of potential symptom trigger along with an acetylcholinesterase inhibitor resulted in remission for up to 4 months. The potentiating effect of donepezil on the cholinergic component of the visuo-amygdaloid pathway/dorsal visual pathway may account for these changes.


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