Design of a Recombinant Hepatitis B Vaccine Based on Stably Binding HLA-I PeptidesMiruka Conrad Ondieki*, Matunda Conradus Nyaribari, Nnamdi John Ejekwumadu and Mokembo Justin Nyakang’o
Department of Bio chemistry Kampala International University P.O BOX 71, Bushenyi Uganda
- *Corresponding Author:
- Miruka Conrad Ondieki
Department of Biochemistry
Kampala International University P.O BOX 71, Bushenyi, Uganda
E-mail: [email protected]
Received date: December 16, 2014; Accepted date: January 16, 2015; Published date: February 02, 2015
Citation: Miruka CO, Matunda NC, Ejekwumadu NJ, Mokembo JN (2015) Design of a Recombinant Hepatitis B Vaccine Based on Stably Binding HLA-I Peptides. J Biomol Res Ther 4:120. doi:10.4172/2167-7956.1000120
Copyright: © 2015 Miruka CO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The hepatitis B virus continues to infect many millions of people worldwide. There is a need to develop new
vaccines against the virus. Using immunoinformatics approaches, we have predicted epitopes within the hepatitis B virus surface antigen that can be used to develop a new vaccine. The predicted epitopes were then used to construct a synthetic vaccine. The interaction between the synthetic vaccine construct and major histocompatibility complex was also predicted using bioinformatics tools.