alexa Design, Synthesis, Characterization and Toxicity Studie
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

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Research Article

Design, Synthesis, Characterization and Toxicity Studies of Poly (N-Iso- Propylacrylamide-co-Lucifer Yellow) Particles for Drug Delivery Applications

Mohsen R1,2*, Alexander BD1, Richardson SCW1, Mitchell JC1, Diab AA2 and Snowden MJ1

1School of Science, University of Greenwich, Chatham, Kent, ME4 4TB, UK

2Faculty of Biotechnology, October University for Modern Sciences and Arts (MSA), Cairo, Egypt

*Corresponding Author:
Reham Mohsen
School of Science, University of Greenwich
Chatham, Kent, ME4 4TB, UK
Tel: 44 (0)20 8331 9800
Fax: 44 (0)20 8331 9805
E-mail: [email protected]

Received Date: March 03, 2016; Accepted Date: March 21, 2016; Published Date: April 02, 2016

Citation: Mohsen R, Alexander BD, Richardson SCW, Mitchell JC, Diab AA, et al. (2016) Design, Synthesis, Characterization and Toxicity Studies of Poly (N-Iso-Propylacrylamide-co-Lucifer Yellow) Particles for Drug Delivery Applications. J Nanomed Nanotechnol 7:363. doi:10.4172/2157-7439.1000363

Copyright: © 2016 Mohsen R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

A novel fluorescent temperature/pH responsive particle was designed, synthesized, characterised and tested for toxicity. Poly (N-iso-propylacrylamide-co-5%-lucifer yellow) (p(NIPAM-co-5% LY)) was prepared using a surfactant free emulsion polymerisation technique. The particles were negatively charged and were approximately 250 nm at 15°C. When the particles de-swell following an increase in temperature, a particle size around 100 nm is obtained. The toxicity of different concentrations of the new particles (p(NIPAM)-co-5% LY, as well as the 100% p(NIPAM) and the main monomer NIPAM was tested on two cell lines (Hela and Vero). The toxicity was tested in comparison to a positive control (dextran sugar) and a negative one (poly(ethylenimine)) (PEI). The results show that the two particles show cell viability over 80% (for both cell lines Hela and Vero) up to a concentration of 3 mg/mL while NIPAM monomer showed cell viability over 80% at a concentration equal to or less than 0.3 mg/mL. The fluorescence property of the novel particles make them traceable. Combining this property (tracing) to the ability of the particles to release their content in response to temperature and pH change can be a potential drug delivery system for cancer treatment.

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