alexa Development and Characterization of Solid-Lipid Micropa
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

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Research Article

Development and Characterization of Solid-Lipid Microparticles of Highly Insoluble Drug Sirolimus

Basavaraj K. Nanjwade*, Didhija J. Patel, Kemy A. Parikh, Veerendra K. Nanjwade and F. V. Manvi

Department of Pharmaceutics, KLE University College of Pharmacy, Belgaum, India

*Corresponding Author:
Dr. Basavaraj K. Nanjwade
Department of Pharmaceutics
KLE University College of Pharmacy
Belgaum, India - 590010
Tel: 00919742431000
Fax: 00918312472387
E-Mail: [email protected]

Received Date: December 07, 2010; Accepted Date: January 24, 2011; Published Date: February 01, 2011

Citation: Nanjwade BK, Patel DJ, Parikh KA, Nanjwade VK, Manvi FV (2011) Development and Characterization of Solid-Lipid Microparticles of Highly Insoluble Drug Sirolimus. J Bioequiv Availab 3: 011-015. doi: 10.4172/jbb.1000050

Copyright: © 2011 Nanjwade BK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Solid lipid microparticles (SLMs) represent an alternative carrier system to traditional colloidal carrier such as emulsion, liposomes and polymeric micro and nanoparticles. The purpose of this research work was to develop and evaluate solid lipid microparticles of sirolimus for oral delivery. Sirolimus is an immunosupressive drug used to prevent transplant rejection and to treat auto immune diseases. It is a macrolide lactone produced by streptomyces hydroscopicus . It is extremely hydrophobic. Sirolimus solid lipid microparticles were prepared by hot homogenization technique. The matrix chiefly consisted of glyceryl monostearate and sodium taurocholate. The SLMs were studied for its particle size analysis, drug content, entrapment efficiency, in vitro release characteristics and also for stability analysis at different temperature and humidity conditions. Average particle size was found to be 21.40μm. Drug content of SLMs determined by HPLC analysis was found to be 98.6±0.31% while entrapment efficiency achieved was 98.02%. Drug release from the final formulation was found to be 90.3% in 90 min. SLMs formulated with glyceryl monostearate and sodium taurocholate can be used for oral delivery of hydrophobic drugs with in-vivo study still to be explored.

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