alexa Development and Validation of a Stability Indicating UPLC Method for Determination of Moxifloxacin Hydrochloride in Pharmaceutical Formulations | OMICS International | Abstract
ISSN : 2153-2435

Pharmaceutica Analytica Acta
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Research Article

Development and Validation of a Stability Indicating UPLC Method for Determination of Moxifloxacin Hydrochloride in Pharmaceutical Formulations

G. Naveen Kumar Reddy1*, V.V.S.Rajendra Prasad2, Nigam Jyoti Maiti3, Diptimayee Nayak3 and Prashant Kumar Maharana4

1Singhania University, Pacheri Bari, Jhunjhunu, Rajasthan

2Sitha Institute of Pharmaceutical Sciences, JNTU, Hyderabad

3Department of Pharmacy, IMT College of Pharmacy, Puri, Odisha

4Mannequin Pharmaceutical, Bhubaneshwar, Odisha

*Corresponding Author:
Dr. G. Naveen Kumar Reddy
Singhania University, Pacheri Bari, Jhunjhunu, Rajasthan
Tel: +91996340443
E-mail: [email protected]

Received date: November 03, 2011; Accepted date: November 18, 2011; Published date: November 21, 2011

Citation: Naveen Kumar Reddy G, Rajendra Prasad VVS, Maiti NJ, Nayak D, Prashant Kumar M (2011) Development and Validation of a Stability Indicating UPLC Method for Determination of Moxifloxacin Hydrochloride in Pharmaceutical Formulations. Pharm Anal Acta 2:142. doi: 10.4172/2153-2435.1000142

Copyright: © 2011 Naveen Kumar Reddy G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Simple, rapid, sensitive, accurate, robust & rugged stability indicating analytical method for determination of Moxifloxacin HCl in pharmaceutical formulations is developed and validated by using UPLC & applied the developed and validated method for determining the assay of Moxifloxacin HCl in tablets (Avelox®), as there is no official monograph & no analytical method by UPLC. Chromatography was performed with mobile phase containing potassium dihydrogen ortho phosphate (adjusted to pH 1.8 with orthophosphoric acid), Methanol & acetonitrile in the ratio of 60:20:20, with a flow rate of 0.3mL/min, C-18 column & UV detection at 296nm.The method was validated for linearity, accuracy, ruggedness, robustness, precision & bench top stability of sample & standard solution. Moxifloxacin tablets were subjected to different stress conditions like acid, alkali, peroxide, thermal, water & UV studies and checked for its specificity, degradation & stability. The developed method was very rapid with a run time of 3 min, accurate, robust, rugged and stable.


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