alexa Development and Validation of Spectrophotometric Method
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

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Research Article

Development and Validation of Spectrophotometric Method for the Determination of Tofisopam in Bulk and Pharmaceutical Formulation

Kokane M*, Pananchery J and Jain A

Department of Quality Assurance, Shri DD Vispute College of Pharmacy and Research Centre, Navi Mumbai, Maharashtra, India

*Corresponding Author:
Megha Sharanappa Kokane
Department of Quality Assurance
Shri. D. D. Vispute College of Pharmacy and Research Center
New Panvel, Navi Mumbai, Maharashtra, 410206, India
Tel: 022-27462888
E-mail: [email protected]

Received date: May 11, 2017; Accepted date: June 20, 2017; Published date: June 26, 2017

Citation: Kokane M, Pananchery J, Jain A (2017) Development and Validation of Spectrophotometric Method for the Determination of Tofisopam in Bulk and Pharmaceutical Formulation. Pharm Anal Acta 8:551. doi: 10.4172/2153-2435.1000551

Copyright: © 2017 Kokane M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



A rapid, specific UV spectrophotometric method has been developed using a solvent methanol to determine Tofisopam content in bulk and pharmaceutical formulations. At a pre-determined wavelength at 310 nm, it was proved linear in the range of 4-24 μg/ml and exhibited good correlation coefficient (R2=0.9996) and excellent mean recovery (98-102%). The method was validated statistically and parameters like linearity, precision, accuracy, specificity, and assay were studied according to International Conference on Harmonization guidelines. The obtained results proved that the method can be employed for the routine analysis of Tofisopam in bulk as well as in the commercial formulations.


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