alexa Effects of Lactate Dehydrogenase (LDH) in Preeclampsia
ISSN: 2471-2663

Clinical & Medical Biochemistry
Open Access

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Research Article

Effects of Lactate Dehydrogenase (LDH) in Preeclampsia

Ababio GK1*, Adu-Bonsaffoh K2, Narh G3, Morvey D4, Botchway F5, Abindau E6, Neequaye J7 and Quaye IKE8

1Department of Medical Biochemistry, University of Ghana School of Biomedical and Allied Health Sciences, Legon, Accra, Ghana

2Department of Obstetrics and Gynaecology, Korle-Bu Teaching Hospital, Accra, Ghana

3Department of Biochemistry, University of Ghana, Accra, Ghana

4Clinical Documentation Improvement Specialist, Southern California Hospital, Culver City, California, USA

5Department of Child Health, Korle-Bu Teaching Hospital, Accra, Ghana

6Department of Physiology, University of Ghana SBAHS, Accra, Ghana

7Biochemistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

8Department of Medical Biochemistry, University of Namibia School of Medicine, Windhoek, Namibia

*Corresponding Author:
Ababio GK
Department of Medical Biochemistry
School of Biomedical and Allied Health Sciences
University of Ghana, P. O. Box 143
Accra, Ghana
Tel: +233 20 8182253
E-mail: [email protected]

Received date: June 20, 2017; Accepted date: July 08, 2017; Published date: July 16, 2017

Citation: Ababio GK, Adu-Bonsaffoh K, Narh G, Morvey D, Botchway F, et al. (2017) Effects of Lactate Dehydrogenase (LDH) in Preeclampsia. . Clin Med Biochem 3: 129. doi:10.4172/2471-2663.1000129

Copyright: © 2017 Ababio GK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background: Lactate dehydrogenase (LDH) is a multifaceted enzyme whose effects in pregnancy related complications e.g., preeclampsia (PE) is now gaining attention. Here we present evidence that LDH levels could contribute significantly to the outcomes of PE. Aim: To determine the effects of LDH in PE. Methodology: The case control study was located at the Obstetrics and Gynaecology department of the KorleBu Teaching Hospital (KBTH). STROBE consensus checklist was adopted. One hundred and forty (140) consented subjects were recruited after ethical clearance was obtained and structured questionnaire administered to them. Four (4) mL blood and 5 mL urine samples were taken for biochemical analysis and urinalysis respectively. Randox and Sysmex automated chemistry analyser was used to quantify blood chemistry. The data was captured as protected health information (PHI) and analysed with SPSS version 22. Results: LDH exposure was associated with higher odds of outcome in preeclampsia (PE) [OR(CI)=4.76(1.26-18.72); p-value=0.0068]. However, with an adjusted OR, LDH categories were associated with birth weight. Notwithstanding the added input, in preeclampsia, increased LDH at <34 weeks of gestation related with decreased birthweight only when platelet, diastolic blood pressure (DBP), pH, bilirubin, parity and liver enzymes each served as covariates in the log linear logit analysis. Conclusion: LDH was associated with low birth weight in PE in a concentration dependent manner under the influence of predictors like pH, platelet and diastolic pressure (DBP) for causality. Therefore, a thoughtful planned foetal delivery under a specific LDH threshold and a regular monitoring of urine pH, full blood count (FBC), and blood pressure might improve the outcomes of PE

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