alexa Effects on Uric Acid Metabolism of the Drugs except the Antihyperuricemics
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

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Review Article

Effects on Uric Acid Metabolism of the Drugs except the Antihyperuricemics

Yuji Moriwaki*

Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, Japan

*Corresponding Author:
Yuji moriwaki
Division of Diabetes
Endocrinology and Metabolism
Department of Internal Medicine
Hyogo College of Medicine
Mukogawa-cho 1-1, Nishinomiya
Hyogo 663-8501, Japan
Fax: +81798456474
E-mail: [email protected]

Received Date: December 01, 2013; Accepted Date: December 30, 2013; Published Date: January 07, 2014

Citation: Moriwaki Y (2014) Effects on Uric Acid Metabolism of the Drugs except the Antihyperuricemics. J Bioequiv Availab 6: 010-017. doi: 10.4172/jbb.1000173

Copyright: © 2014 Moriwaki Y. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A number of drugs commonly used in clinical practice can affect the serum concentration of uric acid. Some raise serum uric acid level by an increase in uric acid production or a decrease in uric acid excretion, while others lower serum uric acid level by an increase in uric acid excretion or decrease in uric acid absorption from intestine. In addition, salicylate shows so-called “biphasic effect”. At small doses it raises serum uric acid level, while at higher doses it lowers serum uric acid concentration. To understand the effects of those pharmacological agents on uric acid metabolism will help to avoid unexpected side effect of hyperuricemia and gout flare. In addition, hypouricemic property of some drugs may obviate the need for polypharmacy and improve the medication compliance.

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