alexa Engineered Protein Polymer-Gold Nanoparticle Hybrid Mat
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

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Research Article

Engineered Protein Polymer-Gold Nanoparticle Hybrid Materials for Small Molecule Delivery

Min Dai1#, Frezzo JA1#, Sharma E1, Chen R1, Singh N1, Yuvienco C1, Caglar E2, Xiao S2, Saxena A2 and Montclare JK1,3,4*

1Department of Chemical and Biomolecular Engineering, NYU Tandon School of Engineering, Brooklyn, New York 11201, USA

2Department of Biology, Brooklyn College and Graduate Center, City University of New York, Brooklyn, New York 11210, USA

3Department of Chemistry, New York University, New York, New York 10003, USA

4Department of Biochemistry, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA

#These authors contributed equally.

*Corresponding Author:
Montclare JK
Department of Chemical and Biomolecular Engineering
NYU Tandon School of Engineering, Brooklyn
New York 11201, USA
Tel: 1-646-997-3679
E-mail: [email protected]

Received Date: November 04, 2015; Accepted Date: February 19, 2016; Published Date: February 29, 2016

Citation: Dai M, Frezzo JA, Sharma E, Chen R, Singh N, et al. (2016) Engineered Protein Polymer-Gold Nanoparticle Hybrid Materials for Small Molecule Delivery. J Nanomed Nanotechnol 7:356. doi:10.4172/2157-7439.1000356

Copyright: © 2016 Dai M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

We have fabricated protein polymer-gold nanoparticle (P-GNP) nanocomposites that exhibit enhanced binding and delivery properties of the small hydrophobic molecule drug, curcumin, to the model breast cancer cell line, MCF-7. These hybrid biomaterials are constructed via in situ GNP templated-synthesis with genetically engineered histidine tags. The P-GNP nanocomposites exhibit enhanced small molecule loading, sustained release and increased uptake by MCF-7 cells. When compared to the proteins polymers alone, the P-GNPs demonstrated a greater than 7-fold increase in curcumin binding, a nearly 50% slower release profile and more than 2-fold increase in cellular uptake of curcumin. These results suggest that P-GNP nanocomposites serve as promising candidates for drug delivery vehicles

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