Enhanced Solubility and Dissolution Rate of Aceclofenac by Using Spray Drying Techniques
Received Date: Dec 17, 2014 / Accepted Date: Jan 04, 2015 / Published Date: Jun 06, 2015
The present study deals with improvement in aqueous solubility of aceclofenac using HPMC K-15M, PVP-K30 and Eudragit RS-100 in varying ratio by spray-drying at optimized condition. The samples of solid dispersion were subjected to fourier transform infra-red spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction morphology (PXRD), scanning electron microscopy (SEM), in vitro drug release and stability studies. A decrease in the melting enthalpy in DSC indicates conversion of crystalline to amorphous state. The results were supported by PXRD, FTIR and SEM data revealed a characteristic decrease in crystallinity. The dissolution studies demonstrated a marked increase in the dissolution rate in comparison with pure drug. The considerable improvement in the dissolution rate of aceclofenac from spray drying, decreased drug crystallinity, altered surface morphology and micronization. The optimized co-crystals exhibited excellent stability on six month storage at accelerated conditions of 40°C and 75% relative humidity. Thus, the solid dispersion obtained by spray drying is a potential tool for improving drug solubility in water.
Keywords: Aceclofenac; Spray drying; Solid dispersion; Polymers; Solubility
Citation: Jethara SI, Patel MR (2015) Enhanced Solubility and Dissolution Rate of Aceclofenac by Using Spray Drying Techniques. Intel Prop Rights 3: 140. Doi: 10.4172/2375-4516.1000140
Copyright: ©2015 Jethara SI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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