Extracellular Matrix Macromolecules in Tumour Microenvironment with Special Reference to Desmoplastic Reaction and the Role of Matrix Proteoglycans and Hyaluronan
- *Corresponding Author:
- Hannu Järveläinen
Turku University Hospital, Division of Endocrinology
Department of Medicine
Kiinamyllynkatu 4-8, Fl-20520 Turku, Finland
Tel: +358 2 333 7583
Fax: +358 2 230 1280
E-mail: [email protected]
Received Date: April 02, 2013; Accepted Date: April 26, 2013; Published Date: May 13, 2013
Citation: Sainio A, Järveläinen H (2013) Extracellular Matrix Macromolecules in Tumour Microenvironment with Special Reference to Desmoplastic Reaction and the Role of Matrix Proteoglycans and Hyaluronan. J Carcinogene Mutagene S13:002. doi: 10.4172/2157-2518.S13-002
Copyright: © 2013 Sainio A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Cancer cells create their own microenvironment via dynamically interacting with the surrounding non-malignant stromal cells and various Extracellular Matrix (ECM) macromolecules as well as with a large number of other proteins within the ECM. The term desmoplastic reaction is used to describe a phenomenon in which ECM macromolecules including specific species of proteoglycans and hyaluronan variously accumulate around the tumour mass. The precise role of the desmoplastic reaction is not known. However, it has been proposed to represent either a defense mechanism by non-malignant host cells against invading cancer cells or to be a tumourigenesis promoting phenomenon induced by cancer cells to assist their propagation. Even an idea that desmoplastic reaction precedes the development of cancer has been introduced, further emphasizing the importance of ECM macromolecules in tumourigenesis. Here, we will discuss ECM macromolecules in tumour microenvironment focusing particularly on desmoplastic reaction and ECM proteoglycans and hyaluronan. We will also present examples of strategies how ECM macromolecules involved in desmoplastic reaction could be considered in the development of innovative oncological pharmacotherapies in the future.