alexa Extracellular Matrix Protein Mindin is Required for the
ISSN: 2155-6121

Journal of Allergy & Therapy
Open Access

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Research Article

Extracellular Matrix Protein Mindin is Required for the Complete Allergic Response to Fungal-Associated Proteinase

Robert M. Tighe1, Erin N. Potts1, Feifei Feng1,3, Zhuowei Li1, Benjamin Frush1, You-Wen He2, David B. Corry4, Paul W. Noble1 and John W. Hollingsworth1,2*

1Department of Medicine, Duke University Medical Center, Durham, NC, USA

2Department of Immunology, Duke University Medical Center, Durham, NC, USA

3Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China

4Departments of Medicine, Pathology, & Immunology, Baylor College of Medicine, Houston, TX, USA

*Corresponding Author:
John W.Hollingsworth M.D
Division of Pulmonary
Allergy, and Critical Care Medicine, Department of Medicine
Duke University School of Medicine, DUMC 103004
106 Research Drive, Durham, NC 27710, USA
Tel: (919)684-4588
Fax: (919)684-5266
E-mail: [email protected]

Received Date: July 29, 2011; Accepted Date: September 06, 2011; Published Date: September 20, 2011

Citation: Tighe RM, Potts EN, Feng F, Li Z, Frush B, et al. (2011) Extracellular Matrix Protein Mindin is Required for the Complete Allergic Response to Fungal-Associated Proteinase. J Aller Ther S1:001. doi: 10.4172/2155-6121.S1-001

Copyright: © 2011 Tighe RM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Asthma remains an important cause of morbidity and mortality with an incidence that continues to rise. Despite the importance of this disease, the mechanisms by which the host develops allergic airways disease remain poorly understood. The development of allergic airways disease appears to be contingent on activation of both the innate and adaptive immune system, but little is known about the cross-talk between these two systems.


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