Abstract

Extracellular Matrix Protein Mindin is Required for the Complete Allergic Response to Fungal-Associated Proteinase

Robert M. Tighe, Erin N. Potts, Feifei Feng, Zhuowei Li, Benjamin Frush, You-Wen He, David B. Corry, John W. Hollingsworth and Paul W. Noble

Asthma remains an important cause of morbidity and mortality with an incidence that continues to rise. Despite the importance of this disease, the mechanisms by which the host develops allergic airways disease remain poorly understood. The development of allergic airways disease appears to be contingent on activation of both the innate and adaptive immune system, but little is known about the cross-talk between these two systems.